PMID- 25087507
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20220321
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 473
IP  - 1-2
DP  - 2014 Oct 1
TI  - Antibacterial efficacy of acridine derivatives conjugated with gold 
      nanoparticles.
PG  - 636-43
LID - S0378-5173(14)00550-X [pii]
LID - 10.1016/j.ijpharm.2014.07.051 [doi]
AB  - Adsorption of acridine derivatives viz. 9-aminoacridine hydrochloride hydrate 
      (9AA-HCl), acridine yellow (AY), acridine orange (AO), and proflavine (Pro) on 
      citrate stabilized gold nanoparticle surface were studied using different 
      analytical techniques like UV-vis absorption spectroscopy, Fourier transform 
      infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM). The 
      amine moiety of acridine derivative binds strongly to the gold nanoparticles as 
      confirmed by spectroscopic studies. The plasmon band observed for the wine red 
      colloidal gold at 525 nm in the UV-vis spectrum is characteristic of gold 
      nanoparticles. However, with the addition of acridine derivatives the intensity 
      of the absorption band at 525 nm decreases and a new peak emerges at red-end 
      region - a signature of formation of gold-drug complex. The TEM images show the 
      average size of citrate stabilized gold nanoparticles as 15-20 nm, which becomes 
      larger in the presence of various drugs due to aggregation. From the 
      thermogravimetric analyses (TGA) we have measured the number of drug molecules 
      attached per gold nanoparticle (AuNP). These gold nanoparticles are very 
      important as drug delivery vehicles and for clinical applications it is necessary 
      to understand their activity in vivo. The antibacterial efficacy of drugs coated 
      gold nanoparticles were studied against various strains of Gram positive and Gram 
      negative bacteria. Among the four drugs, 9AA-HCl and AO showed antibacterial 
      activity and for both of them the AuNP conjugated drug showed better 
      antibacterial efficacy than the bare drug. Because of the high penetrating power 
      and large surface area of Au(0), a single gold nanoparticle can adsorb multiple 
      drug molecules, hence this total entity acts as a single group against the 
      bacteria.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Mitra, Piyali
AU  - Mitra P
AD  - Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, 
      Kolkata 700064, India.
FAU - Chakraborty, Prabal Kumar
AU  - Chakraborty PK
AD  - Crystallography and Molecular Biology Division, Saha Institute of Nuclear 
      Physics, 1/AF, Bidhannagar, Kolkata 700064, India.
FAU - Saha, Partha
AU  - Saha P
AD  - Crystallography and Molecular Biology Division, Saha Institute of Nuclear 
      Physics, 1/AF, Bidhannagar, Kolkata 700064, India.
FAU - Ray, Pulak
AU  - Ray P
AD  - Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 
      1/AF, Bidhannagar, Kolkata 700064, India.
FAU - Basu, Samita
AU  - Basu S
AD  - Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, 
      Kolkata 700064, India. Electronic address: samita.basu@saha.ac.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140801
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Acridines)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Citrates)
RN  - 0 (Drug Carriers)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - *Acridines/administration & dosage/chemistry
MH  - Adsorption
MH  - *Anti-Bacterial Agents/administration & dosage/chemistry
MH  - Bacillus subtilis/drug effects/growth & development/ultrastructure
MH  - Citrates/chemistry
MH  - *Drug Carriers/administration & dosage/chemistry
MH  - Escherichia coli/drug effects/growth & development
MH  - *Gold/administration & dosage/chemistry
MH  - *Metal Nanoparticles/administration & dosage/chemistry/ultrastructure
MH  - Microscopy, Electron, Transmission
OTO - NOTNLM
OT  - Antibacterial efficacy
OT  - Covalently modified
OT  - Nanoparticles
OT  - Transmission electron microscope
EDAT- 2014/08/05 06:00
MHDA- 2015/05/15 06:00
CRDT- 2014/08/05 06:00
PHST- 2014/06/09 00:00 [received]
PHST- 2014/07/25 00:00 [revised]
PHST- 2014/07/26 00:00 [accepted]
PHST- 2014/08/05 06:00 [entrez]
PHST- 2014/08/05 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - S0378-5173(14)00550-X [pii]
AID - 10.1016/j.ijpharm.2014.07.051 [doi]
PST - ppublish
SO  - Int J Pharm. 2014 Oct 1;473(1-2):636-43. doi: 10.1016/j.ijpharm.2014.07.051. Epub 
      2014 Aug 1.