PMID- 25087780
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20141219
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 132
IP  - 1
DP  - 2015 Jan
TI  - Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an 
      anatomically selective fashion.
PG  - 146-54
LID - 10.1111/jnc.12846 [doi]
AB  - Although the causes of psychiatric disorders are not fully understood, it is well 
      established that mental illness originates from the interaction between genetic 
      and environmental factors. In this regard, compelling evidence demonstrates that 
      depression can be the consequence of altered, and often maladaptive, response to 
      adversities during pre- and early post-natal life. In this study, we investigated 
      the impact of chronic maternal separation (MS) on the expression of the 
      neurotrophin brain-derived neurotrophic factor (BDNF) in serotonin transporter 
      (SERT) knockout rats in the ventral and dorsal hippocampus as well as the 
      ventromedial and dorsomedial prefrontal cortex (PFC). We found that both SERT 
      deletion and the MS led to an overall reduction in Bdnf expression in the ventral 
      hippocampus and the ventromedial PFC, whereas in the dorsal hippocampus and in 
      the dorsomedial PFC, we observed a significant increase in the neurotrophin gene 
      expression after MS exposure, specifically in the heterozygous SERT rats. In 
      summary, we show that the modulation of Bdnf expression in SERT mutant rats 
      exposed to MS reflects the complex functional consequences of this 
      gene-environment interaction with a clear distinction between the ventral and the 
      dorsal subfields of the hippocampus and of the PFC. Early life stress differently 
      affects the expression of Bdnf in an anatomically distinct manner as a function 
      of SERT genotype. Specifically, both SERT deletion and the maternal separation 
      (MS) led to an overall reduction in Bdnf expression in the ventral hippocampus 
      and in the ventromedial prefrontal cortex, whereas in the dorsal hippocampus and 
      in the dorsomedial prefrontal cortex, we observed a significant increase in the 
      neurotrophin gene expression after MS exposure specifically in the heterozygous 
      SERT rats. We think that these findings may provide novel cues for modulating 
      neurotrophin function, which is dys-regulated in several psychiatric conditions.
CI  - (c) 2014 International Society for Neurochemistry.
FAU - Calabrese, Francesca
AU  - Calabrese F
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Milan, Italy.
FAU - van der Doelen, Rick H A
AU  - van der Doelen RH
FAU - Guidotti, Gianluigi
AU  - Guidotti G
FAU - Racagni, Giorgio
AU  - Racagni G
FAU - Kozicz, Tamas
AU  - Kozicz T
FAU - Homberg, Judith R
AU  - Homberg JR
FAU - Riva, Marco A
AU  - Riva MA
LA  - eng
SI  - GENBANK/EF125675
SI  - GENBANK/EF125678
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140904
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Animals
MH  - Anxiety, Separation/genetics/psychology
MH  - Brain Chemistry/genetics
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Gene Knockout Techniques
MH  - Hippocampus/metabolism
MH  - Male
MH  - Maternal Deprivation
MH  - Molecular Sequence Data
MH  - Mutation/genetics
MH  - Prefrontal Cortex/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Stress, Psychological/genetics/*metabolism/psychology
OTO - NOTNLM
OT  - maternal separation
OT  - neurotrophin
OT  - serotonin
OT  - ventral and dorsal hippocampus/prefrontal cortex
EDAT- 2014/08/05 06:00
MHDA- 2015/02/20 06:00
CRDT- 2014/08/05 06:00
PHST- 2014/06/25 00:00 [received]
PHST- 2014/07/25 00:00 [revised]
PHST- 2014/07/29 00:00 [accepted]
PHST- 2014/08/05 06:00 [entrez]
PHST- 2014/08/05 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - 10.1111/jnc.12846 [doi]
PST - ppublish
SO  - J Neurochem. 2015 Jan;132(1):146-54. doi: 10.1111/jnc.12846. Epub 2014 Sep 4.