PMID- 25087951
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20220318
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 37
IP  - 8
DP  - 2014
TI  - Anti-allergic effect of bee venom in an allergic rhinitis mouse model.
PG  - 1295-300
AB  - Bee venom (BV) has been used as an anti-inflammatory and immune modulating agent 
      in Oriental medicine. This study used a mouse model to investigate the 
      anti-allergic effect of BV, which is used in the treatment of various 
      inflammatory diseases in traditional medicine. BV was obtained from the National 
      Institute of Agricultural Science and Technology of Korea. Female BALB/C mice 
      were sensitized by intraperitoneal injection of ovalbumin (OVA). BV was 
      administered nasally prior to the intranasal instillation of OVA. Allergic 
      behavior, serum OVA-specific immunoglobulin E (IgE), interleukin (IL)-4, IL-10, 
      and interferon-gamma (INF-gamma) levels in nasal lavage fluid were measured. 
      Hematoxylin-eosin and periodic acid-Schiff staining were performed to evaluate 
      histological change. BV attenuated nasal symptoms and inhibited the production of 
      OVA-specific IgE and IL-4 in sensitized mice. The degree of inflammatory cell 
      infiltration and goblet cell hyperplasia was attenuated by BV. Thus, BV 
      effectively reduced allergic inflammation in a mouse model of allergic rhinitis, 
      suggesting its potential as a useful therapeutic agent to treat allergic 
      rhinitis.
FAU - Shin, Seung-Heon
AU  - Shin SH
AD  - Department of Otolaryngology-Head and Neck Surgery, Catholic University of Daegu.
FAU - Kim, Yee-Hyuk
AU  - Kim YH
FAU - Kim, Jeong-Kyu
AU  - Kim JK
FAU - Park, Kwan-Kyu
AU  - Park KK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Allergens)
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Bee Venoms)
RN  - 0 (Cytokines)
RN  - 0 (Mucins)
RN  - 0 (NF-kappa B)
RN  - 0 (Transcription Factor AP-1)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Anti-Allergic Agents/pharmacology/*therapeutic use
MH  - Bee Venoms/pharmacology/*therapeutic use
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Mice, Inbred BALB C
MH  - Mucins/immunology
MH  - NF-kappa B/immunology
MH  - Nasal Lavage Fluid/immunology
MH  - Nasal Mucosa/drug effects/metabolism/pathology
MH  - Ovalbumin/immunology
MH  - Rhinitis, Allergic/blood/*drug therapy/immunology
MH  - Transcription Factor AP-1/immunology
EDAT- 2014/08/05 06:00
MHDA- 2015/04/07 06:00
CRDT- 2014/08/05 06:00
PHST- 2014/08/05 06:00 [entrez]
PHST- 2014/08/05 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - DN/JST.JSTAGE/bpb/b14-00102 [pii]
AID - 10.1248/bpb.b14-00102 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2014;37(8):1295-300. doi: 10.1248/bpb.b14-00102.