PMID- 25088994
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20140826
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 451
IP  - 2
DP  - 2014 Aug 22
TI  - The role of tumor suppressor menin in IL-6 regulation in mouse islet tumor cells.
PG  - 308-13
LID - S0006-291X(14)01362-X [pii]
LID - 10.1016/j.bbrc.2014.07.113 [doi]
AB  - Menin is a gene product of multiple endocrine neoplasia type1 (Men1), an 
      inherited familial cancer syndrome characterized by tumors of endocrine tissues. 
      To gain insight about how menin performs an endocrine cell-specific tumor 
      suppressor function, we investigated the possibility that menin was integrated in 
      a cancer-associated inflammatory pathway in a cell type-specific manner. Here, we 
      showed that the expression of IL-6, a proinflammatory cytokine, was specifically 
      elevated in mouse islet tumor cells upon depletion of menin and Men(-/-) MEF 
      cells, but not in hepatocellular carcinoma cells. Histone H3 lysine (K) 9 
      methylation, but not H3 K27 or K4 methylation, was involved in menin-dependent 
      IL-6 regulation. Menin occupied the IL-6 promoter and recruited SUV39H1 to induce 
      H3 K9 methylation. Our findings provide a molecular insight that menin-dependent 
      induction of H3 K9 methylation in the cancer-associated interleukin gene might be 
      linked to preventing endocrine-specific tumorigenesis.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Song, Tae-Yang
AU  - Song TY
AD  - School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic 
      of Korea.
FAU - Lim, Jihyeon
AU  - Lim J
AD  - School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic 
      of Korea.
FAU - Kim, Byungho
AU  - Kim B
AD  - School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic 
      of Korea; C&C Research Laboratories, Sungkyunkwan University, Suwon, Gyeonggi-do 
      440-746, Republic of Korea.
FAU - Han, Jeung-Whan
AU  - Han JW
AD  - School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic 
      of Korea.
FAU - Youn, Hong-Duk
AU  - Youn HD
AD  - Department of Biomedical Sciences and Biochemistry and Molecular Biology, 
      National Creative Research Center for Epigenome Reprogramming Network, Seoul 
      National University College of Medicine, Seoul 110-799, Republic of Korea.
FAU - Cho, Eun-Jung
AU  - Cho EJ
AD  - School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic 
      of Korea. Electronic address: echo@skku.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140801
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Interleukin-6)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Men1 protein, mouse)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.1.1.8 (Histamine N-Methyltransferase)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cells, Cultured
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - HeLa Cells
MH  - Hep G2 Cells
MH  - Histamine N-Methyltransferase/metabolism
MH  - Humans
MH  - Insulinoma/*genetics/*metabolism
MH  - Interleukin-6/*genetics/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Pancreatic Neoplasms/*genetics/*metabolism
MH  - Promoter Regions, Genetic
MH  - Proto-Oncogene Proteins/antagonists & inhibitors/deficiency/genetics/*metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Tumor Suppressor Proteins/deficiency/genetics/*metabolism
OTO - NOTNLM
OT  - Histone
OT  - Histone methylation
OT  - Men1
OT  - Menin
OT  - Tumor suppressor
EDAT- 2014/08/05 06:00
MHDA- 2014/10/22 06:00
CRDT- 2014/08/05 06:00
PHST- 2014/07/22 00:00 [received]
PHST- 2014/07/25 00:00 [accepted]
PHST- 2014/08/05 06:00 [entrez]
PHST- 2014/08/05 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
AID - S0006-291X(14)01362-X [pii]
AID - 10.1016/j.bbrc.2014.07.113 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2014 Aug 22;451(2):308-13. doi: 
      10.1016/j.bbrc.2014.07.113. Epub 2014 Aug 1.