PMID- 25089150
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140804
LR  - 20220316
IS  - 1744-859X (Print)
IS  - 1744-859X (Electronic)
IS  - 1744-859X (Linking)
VI  - 13
DP  - 2014
TI  - Serum proBDNF/BDNF and response to fluvoxamine in drug-naive first-episode major 
      depressive disorder patients.
PG  - 19
LID - 10.1186/1744-859X-13-19 [doi]
AB  - BACKGROUND: We investigated the association between serum proBDNF, a precursor of 
      brain-derived neurotrophic factor (BDNF), and response to fluvoxamine in patients 
      with major depressive disorder (MDD) using the Diagnostic and Statistical Manual 
      of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR): physically 
      healthy and free of current alcohol or drug abuse, comorbid anxiety, or 
      personality disorders. METHODS: Fifty-one patients with MDD (M/F, 19:32; age, 
      38 +/- 19 years) and 51 healthy controls (M/F, 22:29; age, 34 +/- 17 years) were 
      studied using DSM-IV-TR: physically healthy and free of current alcohol or drug 
      abuse, comorbid anxiety, or personality disorders. Serum levels of proBDNF and 
      MDNF were measured by sandwich enzyme-linked immunosorbent assay (ELISA). 
      RESULTS: Serum mature BDNF levels in the MDD patients were significantly lower 
      than those in the healthy controls (t = 3.046, p = 0.0018). On the other hand, no 
      difference was found in serum proBDNF between the MDD patients and the healthy 
      controls (t = -0.979, p = 0.833). A trend of negative correlation was found 
      between baseline serum BDNF and baseline scores of the 17 items of the Hamilton 
      Rating Scale for Depression (HAMD17) (r = -0.183, p = 0.071). No correlation was 
      however found between HAMD17 scores and proBDNF at baseline (r = 0.092, 
      p = 0.421). Furthermore, no correlation was observed between baseline HAMD17 
      scores and baseline proBDNF/BDNF (r = -0.130, p = 0.190). No changes were 
      observed in serum levels of proBDNF and BDNF during the treatment periods. 
      CONCLUSIONS: These results suggest that there is no association between serum 
      proBDNF/BDNF and fluvoxamine response in MDD patients at least within 4 weeks of 
      the treatment.
FAU - Yoshimura, Reiji
AU  - Yoshimura R
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu 807-8555, Japan.
FAU - Kishi, Taro
AU  - Kishi T
AD  - Department of Psychiatry, Fujita Health University, Toyoake 470-1192, Japan.
FAU - Hori, Hikaru
AU  - Hori H
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu 807-8555, Japan.
FAU - Atake, Kiyokazu
AU  - Atake K
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu 807-8555, Japan.
FAU - Katsuki, Asuka
AU  - Katsuki A
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu 807-8555, Japan.
FAU - Nakano-Umene, Wakako
AU  - Nakano-Umene W
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu 807-8555, Japan.
FAU - Ikenouchi-Sugita, Atsuko
AU  - Ikenouchi-Sugita A
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu 807-8555, Japan.
FAU - Iwata, Nakao
AU  - Iwata N
AD  - Department of Psychiatry, Fujita Health University, Toyoake 470-1192, Japan.
FAU - Nakamura, Jun
AU  - Nakamura J
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu 807-8555, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140709
PL  - England
TA  - Ann Gen Psychiatry
JT  - Annals of general psychiatry
JID - 101236515
PMC - PMC4118273
OTO - NOTNLM
OT  - BDNF
OT  - Fluvoxamine
OT  - Major depressive disorder
OT  - Serum
OT  - proBDNF
EDAT- 2014/08/05 06:00
MHDA- 2014/08/05 06:01
PMCR- 2014/07/09
CRDT- 2014/08/05 06:00
PHST- 2014/03/11 00:00 [received]
PHST- 2014/06/02 00:00 [accepted]
PHST- 2014/08/05 06:00 [entrez]
PHST- 2014/08/05 06:00 [pubmed]
PHST- 2014/08/05 06:01 [medline]
PHST- 2014/07/09 00:00 [pmc-release]
AID - 1744-859X-13-19 [pii]
AID - 10.1186/1744-859X-13-19 [doi]
PST - epublish
SO  - Ann Gen Psychiatry. 2014 Jul 9;13:19. doi: 10.1186/1744-859X-13-19. eCollection 
      2014.