PMID- 25089684
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20171116
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 496
DP  - 2014 Oct 15
TI  - Prospective associations between persistent organic pollutants and metabolic 
      syndrome: a nested case-control study.
PG  - 219-225
LID - S0048-9697(14)01068-7 [pii]
LID - 10.1016/j.scitotenv.2014.07.039 [doi]
AB  - OBJECTIVE: Exposure to persistent organic pollutants (POPs) has recently been 
      linked to metabolic syndrome (MetS) and some MetS components. However, 
      prospective evidence in humans is scarce, and the nature of the dose-response 
      relationship is unclear. We evaluated the association between POPs and MetS using 
      a nested-case control study within a community-based Korean cohort. METHOD: The 
      study subjects were 64 patients newly diagnosed with MetS during a 4-year 
      follow-up, and the controls were 182 subjects without MetS. Concentrations of 
      polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) were 
      measured in stored serum collected at baseline. RESULTS: The concentrations of 
      most PCBs and some OCPs such as beta-hexachlorocyclohexane, hexachlorobenzene, 
      oxychlordane, and heptachlor epoxide predicted the risk for MetS. The POP 
      exposure and MetS showed an inverted U-shaped or a linear association with 
      plateau rather than a linear dose-response association. When the summary measure 
      of the PCBs and OCPs was used, the adjusted odds ratios (ORs) across the 
      quartiles of the summary measure were 1.0, 1.3, 3.8 (95% confidence interval, 
      1.3-10.7), and 2.1 (Pquadratic=0.013) after adjusting for potential confounders. 
      In the analyses of each of the five MetS components, POP exposure was mainly 
      associated with an increased risk for glucose and lipid metabolism disturbances. 
      CONCLUSION: This study demonstrated that chronic exposure to a mixture of PCBs 
      and OCPs can increase the risk for MetS within the low-dose background exposure 
      range of POPs. As the findings of this study suggest a nonmonotonic dose-response 
      relationship, in vitro and in vivo experimental studies are needed to understand 
      the underlying mechanisms.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Lee, Yu-Mi
AU  - Lee YM
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842, Republic of Korea; 
      Regional Cardiocerebrovascular Center, Kyungpook National University Hospital, 
      130 Dongdeok-ro, Jung-gu, Daegu 700-721, Republic of Korea.
FAU - Kim, Ki-Su
AU  - Kim KS
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842, Republic of Korea.
FAU - Kim, Se-A
AU  - Kim SA
AD  - Department of Biomedical Science, Kyungpook National University, 680 
      Gukchaebosang-ro, Jung-gu, Daegu 700-842, Republic of Korea; BK21 Plus KNU 
      Biomedical Convergence Program, Department of Biomedical Science, Kyungpook 
      National University, Republic of Korea.
FAU - Hong, Nam-Soo
AU  - Hong NS
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842, Republic of Korea.
FAU - Lee, Su-Jin
AU  - Lee SJ
AD  - Department of Epidemiology and Health Promotion, School of Public Health, 
      Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842, 
      Republic of Korea.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842, Republic of Korea; BK21 
      Plus KNU Biomedical Convergence Program, Department of Biomedical Science, 
      Kyungpook National University, Republic of Korea. Electronic address: 
      lee_dh@knu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140802
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Case-Control Studies
MH  - Environmental Exposure/*statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Male
MH  - Metabolic Syndrome/*epidemiology
MH  - Middle Aged
MH  - Odds Ratio
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
OTO - NOTNLM
OT  - Metabolic syndrome
OT  - Organochlorine pesticides
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyls
EDAT- 2014/08/05 06:00
MHDA- 2015/01/13 06:00
CRDT- 2014/08/05 06:00
PHST- 2014/03/13 00:00 [received]
PHST- 2014/06/15 00:00 [revised]
PHST- 2014/07/11 00:00 [accepted]
PHST- 2014/08/05 06:00 [entrez]
PHST- 2014/08/05 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - S0048-9697(14)01068-7 [pii]
AID - 10.1016/j.scitotenv.2014.07.039 [doi]
PST - ppublish
SO  - Sci Total Environ. 2014 Oct 15;496:219-225. doi: 10.1016/j.scitotenv.2014.07.039. 
      Epub 2014 Aug 2.