PMID- 25090987
OWN - NLM
STAT- MEDLINE
DCOM- 20150415
LR  - 20190911
IS  - 1873-5592 (Electronic)
IS  - 1389-4501 (Linking)
VI  - 15
IP  - 9
DP  - 2014
TI  - Progress in intra-articular drug delivery systems for osteoarthritis.
PG  - 888-900
AB  - As the most common form of arthritis, osteoarthritis (OA) is prevalent in the 
      elderly, bringing patients pain and functional limitations of joints. Current 
      medication treatments of OA mainly consist of oral and intra-articular 
      administration. Despite the undeniable advantages over oral administration, the 
      efficacy of intra-articular therapy is still limited by the rapid clearance of 
      drugs. To guarantee the efficacy and avoid frequent injections, rationally 
      designed intra-articular drug delivery systems (DDSs), which may remain in OA 
      joints for a long time and sustainedly release drugs, are clinically in need. In 
      this article, we present a review of the novel intra-articular DDSs for OA 
      treatment reported recently, especially in the last five years. Factors 
      influencing the biocompatibility and efficacy of such systems are also addressed. 
      Moreover, the potential fate of different systems in joints is highlighted. 
      Future innovations in this field may lie in the discovery of effective DMOADs and 
      the development of novel biomaterials as carriers of bioactivity substances.
FAU - Yang, Xiaoye
AU  - Yang X
FAU - Du, Hongliang
AU  - Du H
FAU - Zhai, Guangxi
AU  - Zhai G
AD  - Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua 
      Xilu, Jinan 250012, China. professorgxzhai@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Targets
JT  - Current drug targets
JID - 100960531
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Antirheumatic Agents/*administration & dosage
MH  - Drug Delivery Systems/methods
MH  - Humans
MH  - Injections, Intra-Articular
MH  - Joints/pathology
MH  - Osteoarthritis/*drug therapy/pathology
EDAT- 2014/08/06 06:00
MHDA- 2015/04/16 06:00
CRDT- 2014/08/06 06:00
PHST- 2014/04/16 00:00 [received]
PHST- 2014/07/22 00:00 [revised]
PHST- 2014/07/24 00:00 [accepted]
PHST- 2014/08/06 06:00 [entrez]
PHST- 2014/08/06 06:00 [pubmed]
PHST- 2015/04/16 06:00 [medline]
AID - CDT-EPUB-61583 [pii]
AID - 10.2174/1389450115666140804155830 [doi]
PST - ppublish
SO  - Curr Drug Targets. 2014;15(9):888-900. doi: 10.2174/1389450115666140804155830.