PMID- 25092146
OWN - NLM
STAT- MEDLINE
DCOM- 20150529
LR  - 20211203
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 47
IP  - 2
DP  - 2014 Dec
TI  - Reciprocal interaction between fish TGF-beta1 and IL-1beta is responsible for 
      restraining IL-1beta signaling activity in grass carp head kidney leukocytes.
PG  - 197-204
LID - S0145-305X(14)00204-3 [pii]
LID - 10.1016/j.dci.2014.07.023 [doi]
AB  - In the present study, we found that recombinant grass carp IL-1beta (rgcIL-1beta) 
      simultaneously up-regulated grass carp IL-1beta (gcIL-1beta) and TGF-beta1 (gcTGF-beta1) 
      expression via NF-kappaB and MAPK signaling in grass carp head kidney leukocytes 
      (HKLs), promoting us to clarify whether TGF-beta1 is an effective antagonist in 
      IL-1beta expression and activity. Our results showed that a stimulation of gcIL-1beta 
      on its own expression was noted within 6 h, but gcTGF-beta1 neutralizing antibody 
      prolonged gcIL-1beta autostimulation up to 12 h, indicating a possible inhibitory 
      role of gcTGF-beta1 in regulating gcIL-1beta effect. This notion was reinforced by the 
      fact that recombinant grass carp TGF-beta1 (rgcTGF-beta1) could impede rgcIL-1beta-induced 
      gcIL-1beta gene expression and secretion in a reciprocal manner. Further studies 
      revealed that rgcTGF-beta1 was able to attenuate rgcIL-1beta-induced mRNA expression of 
      its own receptor signaling molecules and the activation of NF-kappaB. By contrast, 
      rgcIL-1beta significantly amplified rgcTGF-beta1-mediated gcTGF-beta1 type I receptor 
      (ALK5) expression and Smad2 phosphorylation in the same cell model. Taken 
      together, these data shed light on an intrinsic mechanism for controlling 
      inflammatory response by the reciprocal interaction between TGF-beta1 and IL-1beta in 
      teleost.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Yang, Xiao
AU  - Yang X
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Wei, He
AU  - Wei H
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Qin, Lei
AU  - Qin L
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Zhang, Shengnan
AU  - Zhang S
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Wang, Xinyan
AU  - Wang X
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Zhang, Anying
AU  - Zhang A
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Du, Linyong
AU  - Du L
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Zhou, Hong
AU  - Zhou H
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China. Electronic address: zhouhongzh@uestc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140801
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Fish Proteins)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Receptors, Transforming Growth Factor beta)
RN  - 0 (Smad2 Protein)
RN  - 0 (Transforming Growth Factor beta1)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.30 (Receptor, Transforming Growth Factor-beta Type I)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing/pharmacology
MH  - Carps
MH  - Feedback, Physiological
MH  - Fish Proteins/genetics/*immunology
MH  - Gene Expression Regulation
MH  - Head Kidney/cytology/*immunology
MH  - Interleukin-1beta/genetics/*immunology/pharmacology
MH  - Leukocytes/cytology/*immunology
MH  - Mitogen-Activated Protein Kinases/genetics/immunology
MH  - NF-kappa B/genetics/immunology
MH  - Phosphorylation/drug effects
MH  - Protein Serine-Threonine Kinases/antagonists & inhibitors/genetics/*immunology
MH  - RNA, Small Interfering/genetics/metabolism
MH  - Receptor, Transforming Growth Factor-beta Type I
MH  - Receptors, Transforming Growth Factor beta/antagonists & 
      inhibitors/genetics/*immunology
MH  - Signal Transduction/*immunology
MH  - Smad2 Protein/genetics/immunology
MH  - Transforming Growth Factor beta1/genetics/*immunology
OTO - NOTNLM
OT  - Grass carp
OT  - Head kidney leukocytes
OT  - IL-1beta
OT  - Reciprocal interaction
OT  - Signaling pathway
OT  - TGF-beta1
EDAT- 2014/08/06 06:00
MHDA- 2015/05/30 06:00
CRDT- 2014/08/06 06:00
PHST- 2014/06/25 00:00 [received]
PHST- 2014/07/28 00:00 [revised]
PHST- 2014/07/28 00:00 [accepted]
PHST- 2014/08/06 06:00 [entrez]
PHST- 2014/08/06 06:00 [pubmed]
PHST- 2015/05/30 06:00 [medline]
AID - S0145-305X(14)00204-3 [pii]
AID - 10.1016/j.dci.2014.07.023 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2014 Dec;47(2):197-204. doi: 10.1016/j.dci.2014.07.023. Epub 
      2014 Aug 1.