PMID- 2509237
OWN - NLM
STAT- MEDLINE
DCOM- 19891124
LR  - 20190908
IS  - 0902-4441 (Print)
IS  - 0902-4441 (Linking)
VI  - 43
IP  - 3
DP  - 1989 Sep
TI  - Red cell aplasia due to host type isohemagglutinins with exuberant red cell 
      progenitor production of donor type in an ABO-mismatched allogeneic bone marrow 
      transplant recipient.
PG  - 195-200
AB  - ABO-mismatched bone marrow transplants have resulted in delayed red cell 
      production in patients who have persistently elevated anti-ABO isohemagglutinin 
      titers. We present a patient with chronic myelogenous leukemia who received an 
      HLA-matched, ABO-incompatible bone marrow transplant from his sister. 
      Post-transplant, he developed pure red cell aplasia with exuberant production of 
      donor red cell precursors by in vitro BFU-E assay. Restriction fragment length 
      polymorphism (RFLP) analysis of bone marrow, peripheral blood and BFU-E colonies 
      demonstrated only donor type DNA post-transplant. However, the patient had 
      persistently elevated isohemagglutinin titer and Ph1 chromosome-positive 
      metaphases on chromosome analysis, indicating the presence of persistent host 
      lymphocytes. With onset of acute graft vs. host disease (GVHD), the 
      isohemagglutinin titer dropped, Ph1 chromosome-positive metaphases disappeared, 
      and full hematopoietic recovery ensued. Longitudinal analysis of RFLP's, 
      isohemagglutinin titers and chromosomes may be helpful in understanding the 
      immunological interplay following allogeneic bone marrow transplantation.
FAU - Cockerill, K J
AU  - Cockerill KJ
AD  - Division of Bone Marrow Transplantation, Pacific Presbyterian Medical Center, San 
      Francisco, California.
FAU - Lyding, J
AU  - Lyding J
FAU - Zander, A R
AU  - Zander AR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
RN  - 0 (ABO Blood-Group System)
RN  - 0 (Hemagglutinins)
SB  - IM
MH  - ABO Blood-Group System/*immunology
MH  - Adult
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Erythroid Precursor Cells/*physiology
MH  - Graft vs Host Disease/etiology
MH  - Hemagglutinins/*analysis
MH  - Humans
MH  - Male
MH  - Philadelphia Chromosome
MH  - Red-Cell Aplasia, Pure/*etiology
MH  - Transplantation, Homologous
EDAT- 1989/09/01 00:00
MHDA- 1989/09/01 00:01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 1989/09/01 00:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
AID - 10.1111/j.1600-0609.1989.tb00282.x [doi]
PST - ppublish
SO  - Eur J Haematol. 1989 Sep;43(3):195-200. doi: 10.1111/j.1600-0609.1989.tb00282.x.