PMID- 25092588
OWN - NLM
STAT- MEDLINE
DCOM- 20150601
LR  - 20181202
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 122
DP  - 2014 Oct 1
TI  - Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer 
      to decrease plasma protein adsorption.
PG  - 529-536
LID - S0927-7765(14)00387-7 [pii]
LID - 10.1016/j.colsurfb.2014.07.025 [doi]
AB  - Lifetime prolongation for hydrophobic drug carriers has been the focus of 
      interest for many years. Poloxamer (Pluronic F68, PF68) has been employed in this 
      study for modifying the surface of magnetic poly(d,l-lactic-co-glycolic acid) 
      (PLGA) nanoparticles (NPs) loaded with human serum albumin (HSA) model drug. 
      Surface characteristics of untreated and PF68 treated NPs were analyzed by size, 
      zeta potential and electrophoretic mobility studies. UV-vis spectroscopic 
      analysis, isothermal titration calorimetry (ITC) and dynamic light scattering 
      methods were used to investigate serum protein (bovine serum albumin, BSA) 
      adsorption. Results showed the successful surface attachment of PF68. Among 
      different concentrations (0.1-1%, wt/vol) of PF68 studied, 0.5% was found to be 
      the most useful, since a higher concentration can issue in micelle formation. 50% 
      less BSA tended to be adsorbed on the treated NPs in comparison to the untreated 
      ones.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Shubhra, Quazi T H
AU  - Shubhra QTH
AD  - Doctoral School of Molecular and Nanotechnologies, Faculty of Information 
      Technology, University of Pannonia, Egyetem u.10, H-8200 Veszprem, Hungary; 
      Research Institute of Chemical and Process Engineering, Faculty of Information 
      Technology, University of Pannonia, Egyetem u.10, H-8200 Veszprem, Hungary. 
      Electronic address: shubhro.du@gmail.com.
FAU - Toth, Judit
AU  - Toth J
AD  - Research Institute of Chemical and Process Engineering, Faculty of Information 
      Technology, University of Pannonia, Egyetem u.10, H-8200 Veszprem, Hungary; 
      Institute of Materials and Environmental Chemistry, Research Centre for Natural 
      Sciences, Hungarian Academy of Sciences, Magyar Tudosok korutja 2, H-1117 
      Budapest, Hungary.
FAU - Gyenis, Janos
AU  - Gyenis J
AD  - Research Institute of Chemical and Process Engineering, Faculty of Information 
      Technology, University of Pannonia, Egyetem u.10, H-8200 Veszprem, Hungary.
FAU - Feczko, Tivadar
AU  - Feczko T
AD  - Research Institute of Chemical and Process Engineering, Faculty of Information 
      Technology, University of Pannonia, Egyetem u.10, H-8200 Veszprem, Hungary; 
      Institute of Materials and Environmental Chemistry, Research Centre for Natural 
      Sciences, Hungarian Academy of Sciences, Magyar Tudosok korutja 2, H-1117 
      Budapest, Hungary.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140722
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Serum Albumin)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Adsorption
MH  - Calorimetry
MH  - Electrophoretic Mobility Shift Assay
MH  - Lactic Acid/*chemistry
MH  - Magnetics
MH  - *Nanoparticles
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Serum Albumin/*chemistry
MH  - Spectrophotometry, Ultraviolet
MH  - Surface Properties
OTO - NOTNLM
OT  - Isothermal titration calorimetry
OT  - Poloxamer
OT  - Protein adsorption
OT  - Surface modification
EDAT- 2014/08/06 06:00
MHDA- 2015/06/02 06:00
CRDT- 2014/08/06 06:00
PHST- 2014/03/01 00:00 [received]
PHST- 2014/05/30 00:00 [revised]
PHST- 2014/07/15 00:00 [accepted]
PHST- 2014/08/06 06:00 [entrez]
PHST- 2014/08/06 06:00 [pubmed]
PHST- 2015/06/02 06:00 [medline]
AID - S0927-7765(14)00387-7 [pii]
AID - 10.1016/j.colsurfb.2014.07.025 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2014 Oct 1;122:529-536. doi: 
      10.1016/j.colsurfb.2014.07.025. Epub 2014 Jul 22.