PMID- 25092675 OWN - NLM STAT- MEDLINE DCOM- 20150311 LR - 20211021 IS - 1939-327X (Electronic) IS - 0012-1797 (Print) IS - 0012-1797 (Linking) VI - 64 IP - 1 DP - 2015 Jan TI - Impaired macromolecular protein pools in fronto-striato-thalamic circuits in type 2 diabetes revealed by magnetization transfer imaging. PG - 183-92 LID - 10.2337/db14-0316 [doi] AB - Previous research has shown that type 2 diabetes mellitus (T2DM) is associated with white matter microstructural changes, cognitive impairment, and decreased resting-state functional connectivity and spontaneous brain activity. This study used magnetization transfer imaging to examine, for the first time, the integrity of macromolecular protein pools in fronto-striato-thalamic circuits and its clinical and cognitive correlates in patients with T2DM. T2DM patients without mood disorders (n = 20, aged 65.05 +/- 11.95 years) and healthy control subjects (HCs; n = 26, aged 62.92 +/- 12.71 years) were recruited. Nodes of fronto-striato-thalamic circuits-head of the caudate nucleus (hCaud), putamen, globus pallidus, thalamus-and four cortical regions-rostral and dorsal anterior cingulate cortex, dorsolateral prefrontal cortex, and lateral orbitofrontal cortex-were examined. Compared with HCs, patients with T2DM had significantly lower magnetization transfer ratio (MTR) in bilateral anterior cingulate and hCaud. Reduced MTRs in the above regions showed correlations with T2DM-related clinical measures, including hemoglobin A1c level and vascular risk factors, and neuropsychological task performance in the domains of learning and memory, executive function, and attention and information processing. The impaired biophysical integrity of brain macromolecular protein pools and their local microenvironments in T2DM patients may provide insights into the neurological pathophysiology underlying diabetes-associated clinical and cognitive deficits. CI - (c) 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. FAU - Yang, Shaolin AU - Yang S AD - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL Department of Radiology, University of Illinois at Chicago, Chicago, IL Department of Bioengineering, University of Illinois at Chicago, Chicago, IL syang@psych.uic.edu akumar@psych.uic.edu. FAU - Ajilore, Olusola AU - Ajilore O AD - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL. FAU - Wu, Minjie AU - Wu M AD - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL. FAU - Lamar, Melissa AU - Lamar M AD - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL. FAU - Kumar, Anand AU - Kumar A AD - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL syang@psych.uic.edu akumar@psych.uic.edu. LA - eng GR - R01-MH63764/MH/NIMH NIH HHS/United States GR - R01 MH063764/MH/NIMH NIH HHS/United States GR - R01-MH73989/MH/NIMH NIH HHS/United States GR - P41 RR015241/RR/NCRR NIH HHS/United States GR - R01 MH073989/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20140804 PL - United States TA - Diabetes JT - Diabetes JID - 0372763 RN - 0 (Macromolecular Substances) SB - IM MH - Aged MH - Atrophy/metabolism/pathology MH - Brain/*metabolism/*pathology MH - Cerebrovascular Circulation MH - Cognition Disorders/metabolism/pathology MH - Corpus Striatum/metabolism/pathology MH - Diabetes Mellitus, Type 2/*metabolism/*pathology MH - Female MH - Frontal Lobe/metabolism/pathology MH - Humans MH - Macromolecular Substances/*metabolism MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Neural Pathways/metabolism/pathology MH - Neuropsychological Tests MH - Thalamus/metabolism/pathology PMC - PMC4274799 EDAT- 2014/08/06 06:00 MHDA- 2015/03/12 06:00 PMCR- 2016/01/01 CRDT- 2014/08/06 06:00 PHST- 2014/08/06 06:00 [entrez] PHST- 2014/08/06 06:00 [pubmed] PHST- 2015/03/12 06:00 [medline] PHST- 2016/01/01 00:00 [pmc-release] AID - db14-0316 [pii] AID - 0316 [pii] AID - 10.2337/db14-0316 [doi] PST - ppublish SO - Diabetes. 2015 Jan;64(1):183-92. doi: 10.2337/db14-0316. Epub 2014 Aug 4.