PMID- 25093068
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140805
LR  - 20231110
IS  - 2041-1480 (Print)
IS  - 2041-1480 (Electronic)
VI  - 5
DP  - 2014
TI  - OAE: The Ontology of Adverse Events.
PG  - 29
LID - 10.1186/2041-1480-5-29 [doi]
AB  - BACKGROUND: A medical intervention is a medical procedure or application intended 
      to relieve or prevent illness or injury. Examples of medical interventions 
      include vaccination and drug administration. After a medical intervention, 
      adverse events (AEs) may occur which lie outside the intended consequences of the 
      intervention. The representation and analysis of AEs are critical to the 
      improvement of public health. DESCRIPTION: The Ontology of Adverse Events (OAE), 
      previously named Adverse Event Ontology (AEO), is a community-driven ontology 
      developed to standardize and integrate data relating to AEs arising subsequent to 
      medical interventions, as well as to support computer-assisted reasoning. OAE has 
      over 3,000 terms with unique identifiers, including terms imported from existing 
      ontologies and more than 1,800 OAE-specific terms. In OAE, the term 'adverse 
      event' denotes a pathological bodily process in a patient that occurs after a 
      medical intervention. Causal adverse events are defined by OAE as those events 
      that are causal consequences of a medical intervention. OAE represents various 
      adverse events based on patient anatomic regions and clinical outcomes, including 
      symptoms, signs, and abnormal processes. OAE has been used in the analysis of 
      several different sorts of vaccine and drug adverse event data. For example, 
      using the data extracted from the Vaccine Adverse Event Reporting System (VAERS), 
      OAE was used to analyse vaccine adverse events associated with the 
      administrations of different types of influenza vaccines. OAE has also been used 
      to represent and classify the vaccine adverse events cited in package inserts of 
      FDA-licensed human vaccines in the USA. CONCLUSION: OAE is a biomedical ontology 
      that logically defines and classifies various adverse events occurring after 
      medical interventions. OAE has successfully been applied in several adverse event 
      studies. The OAE ontological framework provides a platform for systematic 
      representation and analysis of adverse events and of the factors (e.g., vaccinee 
      age) important for determining their clinical outcomes.
FAU - He, Yongqun
AU  - He Y
AD  - University of Michigan, Ann Arbor, MI, USA.
FAU - Sarntivijai, Sirarat
AU  - Sarntivijai S
AD  - University of Michigan, Ann Arbor, MI, USA ; US Food and Drug Administration, 
      Silver Spring, MD, USA.
FAU - Lin, Yu
AU  - Lin Y
AD  - University of Michigan, Ann Arbor, MI, USA.
FAU - Xiang, Zuoshuang
AU  - Xiang Z
AD  - University of Michigan, Ann Arbor, MI, USA.
FAU - Guo, Abra
AU  - Guo A
AD  - University of Michigan, Ann Arbor, MI, USA.
FAU - Zhang, Shelley
AU  - Zhang S
AD  - University of Michigan, Ann Arbor, MI, USA.
FAU - Jagannathan, Desikan
AU  - Jagannathan D
AD  - University of Michigan, Ann Arbor, MI, USA.
FAU - Toldo, Luca
AU  - Toldo L
AD  - Merck KGaA, Darmstadt, Germany.
FAU - Tao, Cui
AU  - Tao C
AD  - University at Texas Health Science Center at Houston, Houston, TX, USA.
FAU - Smith, Barry
AU  - Smith B
AD  - University at Buffalo, Buffalo, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20140705
PL  - England
TA  - J Biomed Semantics
JT  - Journal of biomedical semantics
JID - 101531992
PMC - PMC4120740
OTO - NOTNLM
OT  - Adverse event
OT  - Design pattern
OT  - Drug
OT  - Drug adverse event
OT  - OAE
OT  - Ontology
OT  - Ontology of Adverse Events
OT  - VAERS
OT  - Vaccine
OT  - Vaccine adverse event
EDAT- 2014/08/06 06:00
MHDA- 2014/08/06 06:01
PMCR- 2014/07/05
CRDT- 2014/08/06 06:00
PHST- 2013/06/22 00:00 [received]
PHST- 2014/06/27 00:00 [accepted]
PHST- 2014/08/06 06:00 [entrez]
PHST- 2014/08/06 06:00 [pubmed]
PHST- 2014/08/06 06:01 [medline]
PHST- 2014/07/05 00:00 [pmc-release]
AID - 2041-1480-5-29 [pii]
AID - 10.1186/2041-1480-5-29 [doi]
PST - epublish
SO  - J Biomed Semantics. 2014 Jul 5;5:29. doi: 10.1186/2041-1480-5-29. eCollection 
      2014.