PMID- 25093089
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140805
LR  - 20211021
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 6
IP  - 7
DP  - 2014 Jul
TI  - The potential role of extracellular regulatory kinase in the survival of patients 
      with early stage adenocarcinoma.
PG  - 930-6
LID - 10.3978/j.issn.2072-1439.2014.07.10 [doi]
AB  - BACKGROUND: Lung cancer is among the most common types of neoplasias, and 
      adenocarcinoma is the most frequent histological type. There is currently an 
      extensive search for prognostic biomarkers of nonsmall cell lung cancer (NSCLC). 
      METHODS: We analyzed the correlation of clinical data and patient survival with 
      the levels of activated extracellular regulatory kinase (ERK) in histological 
      samples of surgically resected early stage lung adenocarcinoma. We randomly 
      selected 36 patients with stage I or II lung adenocarcinoma who underwent 
      pulmonary lobectomy between 1998 and 2004. Patients were divided into the 
      following two groups according to immunohistochemical profile: a group with <15% 
      ERK-positive tumor cells and a group with >/=15% ERK-positive tumor cells. For data 
      comparison, an enrichment analysis of a microarray database was performed 
      (GSE29016, n=72). RESULTS: Activated ERK levels were >/=15% and <15% in 21 (58%) 
      and 15 (42%) patients, respectively. There were no statistically significant 
      differences in age, sex, smoking history, and body mass index (BMI) among the 
      groups stratified by ERK levels. The survival rate was lower in the ERK >/=15% 
      group than in the ERK <15% group (P=0.045). Enrichment analyses showed no 
      correlation between variations in gene expression of ERK in patients with 
      adenocarcinoma and survival rates in patients with stage I and combined stage II 
      + III disease. CONCLUSIONS: Our findings suggest that high ERK positivity in 
      cells from biological samples of lung adenocarcinoma is related with tumor 
      aggressiveness and a poorer prognosis.
FAU - de Leon Martini, Simone
AU  - de Leon Martini S
AD  - 1 Programa de Pos-graduacao em Ciencias Pneumologicas, Universidade Federal do 
      Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre (RS), Brazil ; 2 Laboratorio de 
      Pulmao e Vias Aereas, Hospital de Clinicas de Porto Alegre (HCPA), 90035-903, 
      Porto Alegre (RS), Brazil ; 3 Laboratorio de Bioquimica Celular, Departamento de 
      Bioquimica, ICBS/UFRGS, 90035-003 Porto Alegre (RS), Brazil ; 4 Laboratorio de 
      Pesquisa em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre 
      (UFCSPA), 90050-170 Porto Alegre (RS), Brazil ; 5 Instituto Nacional de Ciencia e 
      Tecnologia-Translational em Medicina (INCT-TM), 90035-903 Porto Alegre (RS), 
      Brazil ; 6 Departamento de Cirurgia Toracica, Hospital de Clinicas de Porto 
      Alegre (HCPA), 90035-903, Porto Alegre (RS), Brazil ; 7 Hospital da Crianca Santo 
      Antonio, Santa Casa de Misericordia de Porto Alegre, 90020-090 Porto Alegre (RS), 
      Brazil.
FAU - Muller, Carolina Beatriz
AU  - Muller CB
AD  - 1 Programa de Pos-graduacao em Ciencias Pneumologicas, Universidade Federal do 
      Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre (RS), Brazil ; 2 Laboratorio de 
      Pulmao e Vias Aereas, Hospital de Clinicas de Porto Alegre (HCPA), 90035-903, 
      Porto Alegre (RS), Brazil ; 3 Laboratorio de Bioquimica Celular, Departamento de 
      Bioquimica, ICBS/UFRGS, 90035-003 Porto Alegre (RS), Brazil ; 4 Laboratorio de 
      Pesquisa em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre 
      (UFCSPA), 90050-170 Porto Alegre (RS), Brazil ; 5 Instituto Nacional de Ciencia e 
      Tecnologia-Translational em Medicina (INCT-TM), 90035-903 Porto Alegre (RS), 
      Brazil ; 6 Departamento de Cirurgia Toracica, Hospital de Clinicas de Porto 
      Alegre (HCPA), 90035-903, Porto Alegre (RS), Brazil ; 7 Hospital da Crianca Santo 
      Antonio, Santa Casa de Misericordia de Porto Alegre, 90020-090 Porto Alegre (RS), 
      Brazil.
FAU - Meurer, Rosalva Thereza
AU  - Meurer RT
AD  - 1 Programa de Pos-graduacao em Ciencias Pneumologicas, Universidade Federal do 
      Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre (RS), Brazil ; 2 Laboratorio de 
      Pulmao e Vias Aereas, Hospital de Clinicas de Porto Alegre (HCPA), 90035-903, 
      Porto Alegre (RS), Brazil ; 3 Laboratorio de Bioquimica Celular, Departamento de 
      Bioquimica, ICBS/UFRGS, 90035-003 Porto Alegre (RS), Brazil ; 4 Laboratorio de 
      Pesquisa em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre 
      (UFCSPA), 90050-170 Porto Alegre (RS), Brazil ; 5 Instituto Nacional de Ciencia e 
      Tecnologia-Translational em Medicina (INCT-TM), 90035-903 Porto Alegre (RS), 
      Brazil ; 6 Departamento de Cirurgia Toracica, Hospital de Clinicas de Porto 
      Alegre (HCPA), 90035-903, Porto Alegre (RS), Brazil ; 7 Hospital da Crianca Santo 
      Antonio, Santa Casa de Misericordia de Porto Alegre, 90020-090 Porto Alegre (RS), 
      Brazil.
FAU - Fernandes, Marilda da Cruz
AU  - Fernandes Mda C
AD  - 1 Programa de Pos-graduacao em Ciencias Pneumologicas, Universidade Federal do 
      Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre (RS), Brazil ; 2 Laboratorio de 
      Pulmao e Vias Aereas, Hospital de Clinicas de Porto Alegre (HCPA), 90035-903, 
      Porto Alegre (RS), Brazil ; 3 Laboratorio de Bioquimica Celular, Departamento de 
      Bioquimica, ICBS/UFRGS, 90035-003 Porto Alegre (RS), Brazil ; 4 Laboratorio de 
      Pesquisa em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre 
      (UFCSPA), 90050-170 Porto Alegre (RS), Brazil ; 5 Instituto Nacional de Ciencia e 
      Tecnologia-Translational em Medicina (INCT-TM), 90035-903 Porto Alegre (RS), 
      Brazil ; 6 Departamento de Cirurgia Toracica, Hospital de Clinicas de Porto 
      Alegre (HCPA), 90035-903, Porto Alegre (RS), Brazil ; 7 Hospital da Crianca Santo 
      Antonio, Santa Casa de Misericordia de Porto Alegre, 90020-090 Porto Alegre (RS), 
      Brazil.
FAU - Mariano, Rodrigo
AU  - Mariano R
AD  - 1 Programa de Pos-graduacao em Ciencias Pneumologicas, Universidade Federal do 
      Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre (RS), Brazil ; 2 Laboratorio de 
      Pulmao e Vias Aereas, Hospital de Clinicas de Porto Alegre (HCPA), 90035-903, 
      Porto Alegre (RS), Brazil ; 3 Laboratorio de Bioquimica Celular, Departamento de 
      Bioquimica, ICBS/UFRGS, 90035-003 Porto Alegre (RS), Brazil ; 4 Laboratorio de 
      Pesquisa em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre 
      (UFCSPA), 90050-170 Porto Alegre (RS), Brazil ; 5 Instituto Nacional de Ciencia e 
      Tecnologia-Translational em Medicina (INCT-TM), 90035-903 Porto Alegre (RS), 
      Brazil ; 6 Departamento de Cirurgia Toracica, Hospital de Clinicas de Porto 
      Alegre (HCPA), 90035-903, Porto Alegre (RS), Brazil ; 7 Hospital da Crianca Santo 
      Antonio, Santa Casa de Misericordia de Porto Alegre, 90020-090 Porto Alegre (RS), 
      Brazil.
FAU - Barbachan E Silva, Mariel
AU  - Barbachan E Silva M
AD  - 1 Programa de Pos-graduacao em Ciencias Pneumologicas, Universidade Federal do 
      Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre (RS), Brazil ; 2 Laboratorio de 
      Pulmao e Vias Aereas, Hospital de Clinicas de Porto Alegre (HCPA), 90035-903, 
      Porto Alegre (RS), Brazil ; 3 Laboratorio de Bioquimica Celular, Departamento de 
      Bioquimica, ICBS/UFRGS, 90035-003 Porto Alegre (RS), Brazil ; 4 Laboratorio de 
      Pesquisa em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre 
      (UFCSPA), 90050-170 Porto Alegre (RS), Brazil ; 5 Instituto Nacional de Ciencia e 
      Tecnologia-Translational em Medicina (INCT-TM), 90035-903 Porto Alegre (RS), 
      Brazil ; 6 Departamento de Cirurgia Toracica, Hospital de Clinicas de Porto 
      Alegre (HCPA), 90035-903, Porto Alegre (RS), Brazil ; 7 Hospital da Crianca Santo 
      Antonio, Santa Casa de Misericordia de Porto Alegre, 90020-090 Porto Alegre (RS), 
      Brazil.
FAU - Klamt, Fabio
AU  - Klamt F
AD  - 1 Programa de Pos-graduacao em Ciencias Pneumologicas, Universidade Federal do 
      Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre (RS), Brazil ; 2 Laboratorio de 
      Pulmao e Vias Aereas, Hospital de Clinicas de Porto Alegre (HCPA), 90035-903, 
      Porto Alegre (RS), Brazil ; 3 Laboratorio de Bioquimica Celular, Departamento de 
      Bioquimica, ICBS/UFRGS, 90035-003 Porto Alegre (RS), Brazil ; 4 Laboratorio de 
      Pesquisa em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre 
      (UFCSPA), 90050-170 Porto Alegre (RS), Brazil ; 5 Instituto Nacional de Ciencia e 
      Tecnologia-Translational em Medicina (INCT-TM), 90035-903 Porto Alegre (RS), 
      Brazil ; 6 Departamento de Cirurgia Toracica, Hospital de Clinicas de Porto 
      Alegre (HCPA), 90035-903, Porto Alegre (RS), Brazil ; 7 Hospital da Crianca Santo 
      Antonio, Santa Casa de Misericordia de Porto Alegre, 90020-090 Porto Alegre (RS), 
      Brazil.
FAU - Andrade, Cristiano Feijo
AU  - Andrade CF
AD  - 1 Programa de Pos-graduacao em Ciencias Pneumologicas, Universidade Federal do 
      Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre (RS), Brazil ; 2 Laboratorio de 
      Pulmao e Vias Aereas, Hospital de Clinicas de Porto Alegre (HCPA), 90035-903, 
      Porto Alegre (RS), Brazil ; 3 Laboratorio de Bioquimica Celular, Departamento de 
      Bioquimica, ICBS/UFRGS, 90035-003 Porto Alegre (RS), Brazil ; 4 Laboratorio de 
      Pesquisa em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre 
      (UFCSPA), 90050-170 Porto Alegre (RS), Brazil ; 5 Instituto Nacional de Ciencia e 
      Tecnologia-Translational em Medicina (INCT-TM), 90035-903 Porto Alegre (RS), 
      Brazil ; 6 Departamento de Cirurgia Toracica, Hospital de Clinicas de Porto 
      Alegre (HCPA), 90035-903, Porto Alegre (RS), Brazil ; 7 Hospital da Crianca Santo 
      Antonio, Santa Casa de Misericordia de Porto Alegre, 90020-090 Porto Alegre (RS), 
      Brazil.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC4120169
OTO - NOTNLM
OT  - Lung cancer
OT  - adenocarcinoma
OT  - extracellular regulatory kinase (ERK)
OT  - survival
EDAT- 2014/08/06 06:00
MHDA- 2014/08/06 06:01
PMCR- 2014/07/01
CRDT- 2014/08/06 06:00
PHST- 2014/02/24 00:00 [received]
PHST- 2014/06/10 00:00 [accepted]
PHST- 2014/08/06 06:00 [entrez]
PHST- 2014/08/06 06:00 [pubmed]
PHST- 2014/08/06 06:01 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - jtd-06-07-930 [pii]
AID - 10.3978/j.issn.2072-1439.2014.07.10 [doi]
PST - ppublish
SO  - J Thorac Dis. 2014 Jul;6(7):930-6. doi: 10.3978/j.issn.2072-1439.2014.07.10.