PMID- 25093184 OWN - NLM STAT- MEDLINE DCOM- 20150330 LR - 20211021 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2014 DP - 2014 TI - Neuroendocrine differentiation is a prognostic factor for stage II poorly differentiated colorectal cancer. PG - 789575 LID - 10.1155/2014/789575 [doi] LID - 789575 AB - Neuroendocrine differentiation (NED) in colorectal cancer is an indistinct phenomenon and may define a new cancer subtype, especially in the poorly differentiated colorectal cancer (PDCRC). The clinical features of PDCRC with NED remain controversial, thus confusing the implementation of individualized treatment. This study included 171 patients who underwent surgery from 2000 to 2011 and had pathology-confirmed PDCRC. Each sample was examined by immunohistochemistry for the biological markers of NED, synaptophysin (Syn), and chromogranin (CgA). Patients with Syn(+) and/or CgA(+) cells were classified as NED(+); otherwise, they were NED(-). Data were collected for patients who were followed up for at least two years. NED(+) staining was present in 71 (41.5%) patients. The median survival time was 36.9 months. No survival differences existed between the NED(-) and NED(+) groups (P > 0.05). However, stage II NED(+) patients had a significantly worse prognosis than NED(-) patients (P = 0.018). For the NED(+) group, the median survival was 38.56 months, and the 5-year survival was 65%. For the NED(-) group, the median survival was 53.18 months, and the 5-year survival was 90%. NED is a common event in primary PDCRC. For stage II PDCRC, NED(+) indicates a poor prognosis. FAU - Liu, Yue AU - Liu Y AD - Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education and Key Laboratory of Molecular Biology in Medical Sciences, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Xu, Jinghong AU - Xu J AD - Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Jiao, Yurong AU - Jiao Y AD - Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Hu, Yeting AU - Hu Y AD - Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education and Key Laboratory of Molecular Biology in Medical Sciences, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Yi, Chenghao AU - Yi C AD - Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education and Key Laboratory of Molecular Biology in Medical Sciences, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Li, Qiong AU - Li Q AD - Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education and Key Laboratory of Molecular Biology in Medical Sciences, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Tong, Zhou AU - Tong Z AD - Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Wang, Xiaowei AU - Wang X AD - Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Hu, Lifeng AU - Hu L AD - Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education and Key Laboratory of Molecular Biology in Medical Sciences, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Xiao, Qian AU - Xiao Q AUID- ORCID: 0000-0002-0120-2371 AD - Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education and Key Laboratory of Molecular Biology in Medical Sciences, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Li, Jun AU - Li J AD - Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. FAU - Ding, Kefeng AU - Ding K AD - Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140629 PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 RN - 0 (Biomarkers, Tumor) RN - 0 (Neoplasm Proteins) SB - IM MH - Aged MH - Biomarkers, Tumor/biosynthesis MH - Cell Differentiation/*genetics MH - Colorectal Neoplasms/*genetics/pathology MH - Female MH - Gene Expression Regulation, Neoplastic MH - Humans MH - Kaplan-Meier Estimate MH - Male MH - Middle Aged MH - Neoplasm Proteins/biosynthesis MH - Neoplasm Staging MH - Neuroendocrine Cells/*pathology MH - *Prognosis PMC - PMC4100365 EDAT- 2014/08/06 06:00 MHDA- 2015/03/31 06:00 PMCR- 2014/06/29 CRDT- 2014/08/06 06:00 PHST- 2014/03/09 00:00 [received] PHST- 2014/05/22 00:00 [revised] PHST- 2014/06/10 00:00 [accepted] PHST- 2014/08/06 06:00 [entrez] PHST- 2014/08/06 06:00 [pubmed] PHST- 2015/03/31 06:00 [medline] PHST- 2014/06/29 00:00 [pmc-release] AID - 10.1155/2014/789575 [doi] PST - ppublish SO - Biomed Res Int. 2014;2014:789575. doi: 10.1155/2014/789575. Epub 2014 Jun 29.