PMID- 25095516
OWN - NLM
STAT- MEDLINE
DCOM- 20140909
LR  - 20151119
IS  - 0890-9016 (Print)
IS  - 0890-9016 (Linking)
DP  - 2013
TI  - Novel strategies for immunological monitoring of kidney transplant recipients: 
      from microRNA to alloantibodies.
PG  - 257-67
AB  - Predicting and diagnosing acute kidney allograft rejection by non-invasive 
      biomarkers is a major goal in clinical transplantation research. Such biomarkers 
      can be reduced to the various stages of the alloimmune response, from 
      transcriptional regulation to immunological effector mechanisms. Here, we 
      describe novel insights into exciting areas of transplantation-related biomarker 
      research that may be translated to non-invasive monitoring strategies. First, we 
      will elaborate on microRNAs, which represent stable, small non-coding ribonucleic 
      acid molecules that can specifically regulate gene expression. Secondly, we will 
      discuss novel methods to monitor human leukocyte antigen (HLA)-specific B cells, 
      as well as the anti-HLA antibodies they produce. Incorporation of these new 
      biomarkers and methodologies into cross-platform biomarker panels may help to 
      improve non-invasive prediction and detection of allograft rejection.
FAU - Heidt, Sebastiaan
AU  - Heidt S
FAU - Eikmans, Michael
AU  - Eikmans M
FAU - Roelen, Dave L
AU  - Roelen DL
FAU - Claas, Frans H J
AU  - Claas FH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Transpl
JT  - Clinical transplants
JID - 8812419
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Acute Disease
MH  - B-Lymphocytes/immunology
MH  - Biomarkers
MH  - Cell Lineage/immunology
MH  - Enzyme-Linked Immunospot Assay
MH  - Flow Cytometry
MH  - *Graft Rejection/diagnosis/genetics/immunology
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Isoantibodies/*immunology
MH  - *Kidney Transplantation
MH  - MicroRNAs/*genetics/urine
MH  - Monitoring, Immunologic/*methods
MH  - Sensitivity and Specificity
MH  - Transplantation Tolerance/genetics/immunology
MH  - Transplantation, Homologous
EDAT- 2013/01/01 00:00
MHDA- 2014/09/10 06:00
CRDT- 2014/08/07 06:00
PHST- 2014/08/07 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
PST - ppublish
SO  - Clin Transpl. 2013:257-67.