PMID- 25095530
OWN - NLM
STAT- MEDLINE
DCOM- 20140909
LR  - 20140806
IS  - 0890-9016 (Print)
IS  - 0890-9016 (Linking)
DP  - 2013
TI  - Unravelling the connections between donor specific antibodies and renal allograft 
      pathology.
PG  - 361-5
AB  - The imperfections of early technologies for assessment of human leukocyte antigen 
      (HLA) antibody specificity have been resolved by solid phase micro bead assays, 
      but this has revealed new uncertainties. The relationship between presence of 
      antibody specific for a donor HLA molecule to graft damage and outcomes has had 
      to be re-evaluated. Studies of protocol biopsies have identified a correlation 
      between donor specific antibody and electron microscopy (EM) changes at three 
      months, which do not predict chronic antibody mediated rejection, but that are 
      predicted by EM changes seen on 12-month protocol biopsies. These intriguing 
      results point to the plasticity of the renal endothelium in the earlier 
      post-transplant months, as well as to the reality that the immune system 
      interaction with the endothelium changes with time.
FAU - Chapman, Jeremy R
AU  - Chapman JR
FAU - Wavamunno, Moses
AU  - Wavamunno M
FAU - O'Connell, Philip J
AU  - O'Connell PJ
FAU - Nankivell, Brian J
AU  - Nankivell BJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Transpl
JT  - Clinical transplants
JID - 8812419
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Allografts/immunology/pathology
MH  - Antibody Specificity
MH  - Endothelium, Vascular/cytology/immunology
MH  - Graft Rejection/*immunology/pathology
MH  - HLA Antigens/*immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Isoantibodies/*immunology
MH  - Isoantigens/*immunology
MH  - Kidney/immunology/pathology/ultrastructure
MH  - *Kidney Transplantation
MH  - Microscopy, Electron
EDAT- 2013/01/01 00:00
MHDA- 2014/09/10 06:00
CRDT- 2014/08/07 06:00
PHST- 2014/08/07 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
PST - ppublish
SO  - Clin Transpl. 2013:361-5.