PMID- 25095533
OWN - NLM
STAT- MEDLINE
DCOM- 20140909
LR  - 20140806
IS  - 0890-9016 (Print)
IS  - 0890-9016 (Linking)
DP  - 2013
TI  - Clinical relevance of pre- and post-transplant HLA antibodies, donor-specific, 
      and nondonor-specific HLA antibodies detected by ELISA in renal transplantation.
PG  - 385-91
AB  - Human leukocyte antigen (HLA) antibodies reactive to donor antigens (DSA) and 
      non-donor specific antigens (NDSA) were detected by enzyme-linked immunosorbent 
      assay (ELISA) to determine their impact on long-term graft survival. Among 162 
      patients who had no pre-transplant HLA antibodies, 5-year graft survival was 87%. 
      There was a significant difference compared with 72% for 18 patients who had 
      pre-transplant HLA antibodies (p=0.031). There was a significant difference in 
      graft survival between patients with pre-transplant NDSA and those without HLA 
      antibodies (p=0.0005), but there was not between patients with pre-transplant DSA 
      and those without HLA antibodies (p=0.615). Among 148 patients who had no 
      post-transplant HLA antibodies, 5-year graft survival was 86%. There was no 
      significant difference compared with 85% for 32 patients who had post-transplant 
      HLA antibodies (p=0.118). There was a significant difference in graft survival 
      between patients with post-transplant DSA and those without HLA antibodies 
      (p=0.006), but there was not between patients with post-transplant NDSA and those 
      without HLA antibodies (p=0.599). In conclusion, pre-transplant NDSA and 
      post-transplant DSA were associated with poor long-term graft survival. For 
      patients who had persistent pre- and post-transplant HLA antibodies, the worst 
      long-term survival could be found. We believe HLA antibody analysis by ELISA is 
      still very useful for transplantation.
FAU - Lee, Po-Chang
AU  - Lee PC
FAU - Chen, Yi Lin
AU  - Chen YL
FAU - Wang, Wei-Ming
AU  - Wang WM
FAU - Tu, Wan Chi
AU  - Tu WC
FAU - Chen, Hsuan Yu
AU  - Chen HY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Transpl
JT  - Clinical transplants
JID - 8812419
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adult
MH  - Antibody Specificity
MH  - Autoantibodies/blood/immunology
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Graft Rejection/*immunology/*mortality
MH  - Graft Survival/*immunology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Isoantibodies/blood/immunology
MH  - Kidney Transplantation/*mortality/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Predictive Value of Tests
MH  - Preoperative Period
MH  - Seroepidemiologic Studies
MH  - Tissue Donors
EDAT- 2013/01/01 00:00
MHDA- 2014/09/10 06:00
CRDT- 2014/08/07 06:00
PHST- 2014/08/07 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
PST - ppublish
SO  - Clin Transpl. 2013:385-91.