PMID- 25095539
OWN - NLM
STAT- MEDLINE
DCOM- 20140909
LR  - 20140806
IS  - 0890-9016 (Print)
IS  - 0890-9016 (Linking)
DP  - 2013
TI  - HLA-specific antibody distribution in renal transplant waiting list patients: 
      utility of antigen frequency data in the definition of HLA-reactive epitopes.
PG  - 433-40
AB  - The use of single antigen bead (SAB) technology has allowed for previously 
      unheralded levels of antibody detection, both in terms of sensitivity and 
      specificity. Human leukocyte antigen (HLA) specific antibody profiles can now be 
      defined in clinically relevant timescales. However, a degree of expertise is 
      still required in order to interpret SAB data and accurately assign antibodies to 
      the epitope level. This study describes how the use of antigen frequency data can 
      be used to support the identification of HLA-reactive epitopes. It also 
      highlights how sharing of epitopes can explain SAB reactivity against HLA 
      antigens found at extremely low frequency in the population.
FAU - Lowe, David
AU  - Lowe D
FAU - Jones, James
AU  - Jones J
FAU - Middleton, Derek
AU  - Middleton D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Transpl
JT  - Clinical transplants
JID - 8812419
RN  - 0 (Antibodies)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies/blood/*immunology
MH  - Antibody Specificity
MH  - Epitopes/*immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Immunoassay/*methods
MH  - *Kidney Transplantation
MH  - Microspheres
MH  - Sensitivity and Specificity
MH  - Seroepidemiologic Studies
MH  - *Waiting Lists
EDAT- 2013/01/01 00:00
MHDA- 2014/09/10 06:00
CRDT- 2014/08/07 06:00
PHST- 2014/08/07 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
PST - ppublish
SO  - Clin Transpl. 2013:433-40.