PMID- 25095540
OWN - NLM
STAT- MEDLINE
DCOM- 20140909
LR  - 20140806
IS  - 0890-9016 (Print)
IS  - 0890-9016 (Linking)
DP  - 2013
TI  - HLA matching at the epitope level: the way to go.
PG  - 441-51
AB  - Human leukocyte antigen (HLA) mismatches are important risk factors for 
      antibody-mediated rejection and transplant failure. With the realization that 
      HLAantibodies recognize epitopes rather than antigens, it has become apparent 
      that donor-recipient compatibility should be assessed at the epitope level. 
      Recent developments have increased our understanding of the structural basis of 
      HLA antigenicity (i.e. the reactivity with specific antibody) and immunogenicity 
      (i.e. the ability to induce an antibody response). HLAMatchmaker is a computer 
      algorithm that considers each HLA antigen as a series of small configurations of 
      polymorphic residues, referred to as eplets, as essential components of HLA 
      epitopes. This chapter addresses the relevance of determining epitope 
      specificities of HLA antibodies in the identification of acceptable mismatches 
      for sensitized patients considered for transplantation. Permissible mismatching 
      for non-sensitized patients aimed to prevent or reduce HLA antibody responses 
      could consider epitope loads of mismatched antigens and the recently developed 
      concepts about the physiochemical basis of immunogenic epitopes and the 
      nonself-self paradigm of eplet immunogenicity.
FAU - Duquesnoy, Rene J
AU  - Duquesnoy RJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Transpl
JT  - Clinical transplants
JID - 8812419
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies/blood/*immunology
MH  - Antibody Specificity/immunology
MH  - Epitope Mapping/*methods
MH  - Evidence-Based Practice
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Immunophenotyping
MH  - *Organ Transplantation
MH  - *Transplantation Immunology
EDAT- 2013/01/01 00:00
MHDA- 2014/09/10 06:00
CRDT- 2014/08/07 06:00
PHST- 2014/08/07 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
PST - ppublish
SO  - Clin Transpl. 2013:441-51.