PMID- 25095541
OWN - NLM
STAT- MEDLINE
DCOM- 20140909
LR  - 20201226
IS  - 0890-9016 (Print)
IS  - 0890-9016 (Linking)
DP  - 2013
TI  - Evolution of studies of HLA class I antigen processing machinery (APM) components 
      in malignant cells.
PG  - 453-63
AB  - Following a description of the way studies of human leukocyte antigen (HLA) class 
      I antigen expression by tumor cells have evolved through the years, the 
      literature related to the frequency of defects in HLA class I antigen processing 
      machinery (APM) component expression in various types of malignancies is 
      reviewed. In addition, the clinical significance of defects in HLA class I APM 
      components as well as the underlying molecular mechanisms are described. Lastly, 
      potential strategies to overcome the defects in HLAclass I APM component 
      expression and function are discussed. The information presented indicates a 
      revival of the interest in the characterization of HLA class I APM component 
      expression by tumor cells since these molecules may play an important role in the 
      outcome of immunotherapy with inhibitory checkpoint molecule-specific monoclonal 
      antibodies in patients with malignant disease. Furthermore, they may represent a 
      useful prognostic biomarker to select patients who might benefit from these types 
      of immunotherapy.
FAU - Sabbatino, Francesco
AU  - Sabbatino F
FAU - Schwab, Joseph H
AU  - Schwab JH
FAU - Ferrone, Soldano
AU  - Ferrone S
FAU - Ferrone, Cristina R
AU  - Ferrone CR
LA  - eng
GR  - R01CA110249/CA/NCI NIH HHS/United States
GR  - R01CA138188/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Clin Transpl
JT  - Clinical transplants
JID - 8812419
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*immunology/therapeutic use
MH  - Antigen Presentation/*immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Neoplasms/*immunology/therapy
EDAT- 2013/01/01 00:00
MHDA- 2014/09/10 06:00
CRDT- 2014/08/07 06:00
PHST- 2014/08/07 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
PST - ppublish
SO  - Clin Transpl. 2013:453-63.