PMID- 25095542
OWN - NLM
STAT- MEDLINE
DCOM- 20140909
LR  - 20231213
IS  - 0890-9016 (Print)
IS  - 0890-9016 (Linking)
DP  - 2013
TI  - The non-classical antigens of HLA-G and HLA-E as diagnostic and prognostic 
      biomarkers and as therapeutic targets in transplantation and tumors.
PG  - 465-72
AB  - The non-classical human leukocyte antigen (HLA) class I antigen HLA-G represents 
      a tolerogenic molecule and is involved in the inhibition of natural killer cell 
      and cytotoxic T lymphocyte-mediated cytotoxicity. Under physiological conditions, 
      HLA-G expression is mainly restricted to immune-privileged tissues, whereas it is 
      overexpressed in tumors and transplants as well as in virus-infected cells. Due 
      to its immunosuppressive features, HLA-G is important for pregnancy or organ 
      transplantation and autoimmune diseases as well as cancer immune escape. This 
      review focusses on the expression, regulation, and function of HLA-G in tumor 
      cells andlor in transplants as well as therapeutic tools for enhancing 
      (transplantation) or avoiding (tumor) tolerance. Thus, HLA-G or HLA-G-derived 
      synthetic molecules might be used as therapeutic agents in combination with 
      immunosuppressive drugs to enhance organ tolerance upon transplantation. In 
      addition, HLA-G neoexpressing tumor cells could be targeted by HLA-G-specific 
      microRNAs in order to enhance tumor immunogenicity.
FAU - Seliger, Barbara
AU  - Seliger B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Transpl
JT  - Clinical transplants
JID - 8812419
RN  - 0 (Biomarkers)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Biomarkers
MH  - HLA-G Antigens/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Neoplasms/*immunology/therapy
MH  - Prognosis
MH  - Transplantation Immunology/*immunology
MH  - HLA-E Antigens
EDAT- 2013/01/01 00:00
MHDA- 2014/09/10 06:00
CRDT- 2014/08/07 06:00
PHST- 2014/08/07 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
PST - ppublish
SO  - Clin Transpl. 2013:465-72.