PMID- 25095762
OWN - NLM
STAT- MEDLINE
DCOM- 20160609
LR  - 20220321
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 28
IP  - 5
DP  - 2015 Oct
TI  - Homocysteine, cysteine, folate and vitamin B(1)(2) status in type 2 diabetic patients 
      with chronic kidney disease.
PG  - 571-6
LID - 10.1007/s40620-014-0126-4 [doi]
AB  - BACKGROUND: Hyperhomocysteinemia (hHcy) is a risk factor in the progression of 
      chronic kidney disease (CKD). In type 2 diabetes (T2D), hHcy is strongly 
      associated with increased risk of cardiovascular disease. Vitamin B12 and folic 
      acid supplementation have been reported to lower homocysteine (tHcy) levels, but 
      no data on plasma tHcy, cysteine (Cys), folate and vitamin B12 levels in T2D-CKD 
      patients are reported. PROCEDURES: tHcy and Cys levels were analyzed in 178 
      T2D-CKD patients by high performance liquid chromatography (HPLC) with 
      fluorescence detection. In addition, we determined folate and vitamin B12 levels 
      using a chemiluminescence method. RESULTS: tHcy and Cys levels were increased in 
      T2D patients, and this rise positively correlated with the CKD stage (P < 0.001). 
      Folate levels were comparable to controls at various CKD stages, whereas vitamin 
      B12 levels were lower, except at stage IV. We did not find any correlation 
      between B-vitamins and levels of tHcy and Cys, regardless of the CKD stage. 
      CONCLUSIONS: This is the first study reporting tHcy, Cys and B-vitamins status in 
      T2D-CKD patients. Although limited to our cohort of 178 patients, our findings 
      could be helpful in clarifying the conflicting literature regarding B-vitamins 
      supplementation. Further studies are necessary before any Hcy-lowering therapy 
      can be safely established in T2D-CKD subjects.
FAU - Pastore, Anna
AU  - Pastore A
AD  - Metabolomic and Proteomic Unit, Children's Hospital "Bambino Gesu", IRCCS, P.zza 
      S. Onofrio, 4, 00165, Rome, Italy. anna.pastore@opbg.net.
FAU - Noce, Annalisa
AU  - Noce A
AD  - Department of Internal Medicine, Nephrology and Hypertension Unit, "Tor Vergata" 
      University Hospital, Rome, Italy.
FAU - Di Giovamberardino, Gianna
AU  - Di Giovamberardino G
AD  - Metabolomic and Proteomic Unit, Children's Hospital "Bambino Gesu", IRCCS, P.zza 
      S. Onofrio, 4, 00165, Rome, Italy.
FAU - De Stefano, Alessandro
AU  - De Stefano A
AD  - Department of Laboratory Medicine, "Tor Vergata" University Hospital, Rome, 
      Italy.
FAU - Calla, Cinzia
AU  - Calla C
AD  - Department of Laboratory Medicine, "Policlinico Gemelli" University Hospital, 
      Rome, Italy.
FAU - Zenobi, Rossella
AU  - Zenobi R
AD  - Department of Laboratory Medicine, "Tor Vergata" University Hospital, Rome, 
      Italy.
FAU - Dessi, Mariarita
AU  - Dessi M
AD  - Department of Laboratory Medicine, "Tor Vergata" University Hospital, Rome, 
      Italy.
FAU - Di Daniele, Nicola
AU  - Di Daniele N
AD  - Department of Internal Medicine, Nephrology and Hypertension Unit, "Tor Vergata" 
      University Hospital, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20140806
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - K848JZ4886 (Cysteine)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Chromatography, High Pressure Liquid
MH  - Cysteine/*blood
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Disease Progression
MH  - Female
MH  - Folic Acid/*blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Male
MH  - Renal Insufficiency, Chronic/*blood/complications
MH  - Vitamin B 12/*blood
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Cysteine
OT  - Folate
OT  - Homocysteine
OT  - Type 2 diabetes
OT  - Vitamin B12
EDAT- 2014/08/07 06:00
MHDA- 2016/06/10 06:00
CRDT- 2014/08/07 06:00
PHST- 2014/04/07 00:00 [received]
PHST- 2014/07/20 00:00 [accepted]
PHST- 2014/08/07 06:00 [entrez]
PHST- 2014/08/07 06:00 [pubmed]
PHST- 2016/06/10 06:00 [medline]
AID - 10.1007/s40620-014-0126-4 [pii]
AID - 10.1007/s40620-014-0126-4 [doi]
PST - ppublish
SO  - J Nephrol. 2015 Oct;28(5):571-6. doi: 10.1007/s40620-014-0126-4. Epub 2014 Aug 6.