PMID- 25096209
OWN - NLM
STAT- MEDLINE
DCOM- 20171215
LR  - 20171215
IS  - 1603-6824 (Electronic)
IS  - 0041-5782 (Linking)
VI  - 176
IP  - 6
DP  - 2014 Mar 17
TI  - [Proton pump inhibitors in peptic ulcer bleeding].
LID - V08130529 [pii]
AB  - Treatment with proton pump inhibitors (PPI) is shown to improve the outcome of 
      peptic ulcer bleeding (PUB). A recent Cochrane review evaluated different regimes 
      of PPI-treatment in the management of PUB. The current evidence suggests that 
      treatment with high-dose PPI (cumulative PPI-dose > 600 mg for the first 72 
      hours) is not associated with an improved outcome compared to treatment with a 
      lower dose of PPI. The available studies are, however, characterized by high risk 
      of bias, insufficient blinding, and a low event rate. Therefore, the existing 
      data are insufficient to conclude that lower doses of PPI are equally efficacious 
      to high-dose treatment. As the current evidence is strongest for high-dose 
      treatment for patients with serious PUB it is recommended to use high-dose PPI 
      treatment in patients treated with endoscopic therapy. This is in line with the 
      national recommendations in Denmark.
FAU - Laursen, Stig Borbjerg
AU  - Laursen SB
AD  - Medicinsk Gastroenterologisk Afdeling S, Odense Universistetshospital, Sdr. 
      Boulevard 29, 5000 Odense C. stig.laursen@rsyd.dk.
FAU - Schaffalitzky de Muckadell, Ove B
AU  - Schaffalitzky de Muckadell OB
LA  - dan
PT  - Journal Article
PL  - Denmark
TA  - Ugeskr Laeger
JT  - Ugeskrift for laeger
JID - 0141730
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Humans
MH  - Peptic Ulcer Hemorrhage/*drug therapy/pathology
MH  - *Proton Pump Inhibitors/administration & dosage/therapeutic use
MH  - Review Literature as Topic
EDAT- 2014/08/07 06:00
MHDA- 2014/08/07 06:01
CRDT- 2014/08/07 06:00
PHST- 2014/08/07 06:00 [entrez]
PHST- 2014/08/07 06:00 [pubmed]
PHST- 2014/08/07 06:01 [medline]
AID - V08130529 [pii]
PST - ppublish
SO  - Ugeskr Laeger. 2014 Mar 17;176(6):V08130529.