PMID- 25096371
OWN - NLM
STAT- MEDLINE
DCOM- 20150701
LR  - 20141105
IS  - 1939-6376 (Electronic)
IS  - 1939-6368 (Linking)
VI  - 60
IP  - 6
DP  - 2014 Dec
TI  - Different segregation patterns in five carriers due to a pericentric inversion of 
      chromosome 1.
PG  - 367-72
LID - 10.3109/19396368.2014.948580 [doi]
AB  - Pericentric inversion can produce recombinant gametes; however, meiotic 
      segregation studies on the relationship between the frequency of recombinants and 
      the inverted segment size are rare. Triple-color fluorescence in situ 
      hybridization (FISH) was performed to analyze the meiotic behavior in five inv(1) 
      carriers with different breakpoints. Recombination gametes were absent in Patient 
      1, whereas the percentages of the recombinants in Patients 2, 3, 4, and 5 were of 
      9.2%, 15.3%, 17.3%, and 40.9%, respectively. A significant difference was present 
      for the frequencies of the recombinant spermatozoa among the five patients (p < 
      0.001). For each patient, the frequency of the two types of recombinant gametes 
      (dup(1p)/del(1q) or del(1p)/dup(1q)) did not exhibit a significant difference in 
      comparison with the expected 1:1 ratio (p > 0.05). The meiotic segregation of 
      nine inv(1) carriers (including those presented in this paper) is now available. 
      A significant correlation was discovered between the rate of recombination and 
      the proportion of the chromosome implicated in the inversion (R = 0.9435, p < 
      0.001). The frequency of the recombinant gametes was directly related to the 
      proportion of the chromosome that was inverted. Sperm-FISH allowed an additional 
      comprehension of the patterns of meiotic segregation and provided accurate 
      genetic counseling.
FAU - Luo, Yuqin
AU  - Luo Y
AD  - Department of Reproductive Genetics, Women's Hospital, Zhejiang University School 
      of Medicine , Hangzhou , China .
FAU - Xu, Chenming
AU  - Xu C
FAU - Sun, Yixi
AU  - Sun Y
FAU - Wang, Liya
AU  - Wang L
FAU - Chen, Songchang
AU  - Chen S
FAU - Jin, Fan
AU  - Jin F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140806
PL  - England
TA  - Syst Biol Reprod Med
JT  - Systems biology in reproductive medicine
JID - 101464963
SB  - IM
MH  - Adult
MH  - Chromosome Breakpoints
MH  - *Chromosome Inversion
MH  - *Chromosome Segregation
MH  - *Chromosomes, Human, Pair 1
MH  - Fertility/genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*genetics/pathology/physiopathology
MH  - Male
MH  - *Meiosis
MH  - Phenotype
MH  - Recombination, Genetic
MH  - Sperm Count
MH  - Sperm Motility
MH  - Spermatozoa/*pathology
OTO - NOTNLM
OT  - Chromosome 1
OT  - infertility
OT  - meiotic segregation
OT  - pericentric inversion
OT  - sperm FISH
EDAT- 2014/08/07 06:00
MHDA- 2015/07/02 06:00
CRDT- 2014/08/07 06:00
PHST- 2014/08/07 06:00 [entrez]
PHST- 2014/08/07 06:00 [pubmed]
PHST- 2015/07/02 06:00 [medline]
AID - 10.3109/19396368.2014.948580 [doi]
PST - ppublish
SO  - Syst Biol Reprod Med. 2014 Dec;60(6):367-72. doi: 10.3109/19396368.2014.948580. 
      Epub 2014 Aug 6.