PMID- 25097660
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140806
LR  - 20211021
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2014
DP  - 2014
TI  - Xiao Yao San Improves Depressive-Like Behavior in Rats through Modulation of 
      beta-Arrestin 2-Mediated Pathways in Hippocampus.
PG  - 902516
LID - 10.1155/2014/902516 [doi]
LID - 902516
AB  - Xiao Yao San (XYS) is a classical Chinese medicine formula that has been widely 
      used to treat mood disorders for hundreds of years. To confirm the effect of XYS 
      and better understand its underlying mechanism, high-performance liquid 
      chromatography-mass spectrometry analysis-based quality control of XYS extracts 
      and proteomics-based identification of differential proteins in the hippocampus 
      were adopted in social isolation and chronic unpredictable mild stress- (CUMS-) 
      treated rats. The depressive-like behavior of rats induced by CUMS resembled the 
      manifestation of human depression. The upregulated corticosterone (CORT) and 
      urocortin 2 (UCN2) levels demonstrated the existence of 
      hypothalamic-pituitary-adrenal (HPA) axis hyperactivity. XYS was effective in 
      ameliorating the depressive-like behavior and downregulating UCN2 and CORT. XYS 
      decreased the expression of serine/threonine-protein phosphatase 2A subunit B and 
      increased the expression of beta-arrestin 2. The expressions of brain-derived 
      neurotrophic factor (BDNF), tyrosine receptor kinase B (TrkB), and mammalian 
      target of rapamycin (mTOR) were also elevated by XYS. In conclusion, XYS improves 
      social isolation and CUMS-induced depressive-like behavior and ameliorates HPA 
      hyperactivation through the downregulation of corticotrophin releasing hormone 
      (CRH) receptor 2. The upregulation of BDNF/TrkB and the phosphorylation of mTOR 
      require beta-arrestin 2 as a scaffold to regulate stress signaling.
FAU - Zhu, Xiaoxia
AU  - Zhu X
AD  - Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical 
      University, No. 1838, Guangzhou 510515, China ; The Key Laboratory of Molecular 
      Biology, State Administration of Traditional Chinese Medicine, School of 
      Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 
      510515, China.
FAU - Xia, Oudong
AU  - Xia O
AD  - The Key Laboratory of Molecular Biology, State Administration of Traditional 
      Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical 
      University, Guangzhou, Guangdong 510515, China ; Dean's Office, Zhujiang 
      Hospital, Southern Medical University, Guangzhou 510282, China.
FAU - Han, Weili
AU  - Han W
AD  - Hygiene Detection Center, School of Public Health and Tropical Medicine, Southern 
      Medical University, Guangzhou 510515, China.
FAU - Shao, Meng
AU  - Shao M
AD  - The Key Laboratory of Molecular Biology, State Administration of Traditional 
      Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical 
      University, Guangzhou, Guangdong 510515, China.
FAU - Jing, Linlin
AU  - Jing L
AD  - Traditional Chinese Medicine Integrated Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510305, China.
FAU - Fan, Qin
AU  - Fan Q
AD  - The Key Laboratory of Molecular Biology, State Administration of Traditional 
      Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical 
      University, Guangzhou, Guangdong 510515, China.
FAU - Liu, Yuanliang
AU  - Liu Y
AD  - The Key Laboratory of Molecular Biology, State Administration of Traditional 
      Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical 
      University, Guangzhou, Guangdong 510515, China.
FAU - Diao, Jianxin
AU  - Diao J
AD  - The Key Laboratory of Molecular Biology, State Administration of Traditional 
      Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical 
      University, Guangzhou, Guangdong 510515, China.
FAU - Lv, Zhiping
AU  - Lv Z
AD  - Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical 
      University, No. 1838, Guangzhou 510515, China ; The Key Laboratory of Molecular 
      Biology, State Administration of Traditional Chinese Medicine, School of 
      Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 
      510515, China.
FAU - Sun, Xuegang
AU  - Sun X
AD  - Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical 
      University, No. 1838, Guangzhou 510515, China ; The Key Laboratory of Molecular 
      Biology, State Administration of Traditional Chinese Medicine, School of 
      Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 
      510515, China.
LA  - eng
PT  - Journal Article
DEP - 20140707
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4109698
EDAT- 2014/08/07 06:00
MHDA- 2014/08/07 06:01
PMCR- 2014/07/07
CRDT- 2014/08/07 06:00
PHST- 2014/03/25 00:00 [received]
PHST- 2014/05/26 00:00 [revised]
PHST- 2014/06/04 00:00 [accepted]
PHST- 2014/08/07 06:00 [entrez]
PHST- 2014/08/07 06:00 [pubmed]
PHST- 2014/08/07 06:01 [medline]
PHST- 2014/07/07 00:00 [pmc-release]
AID - 10.1155/2014/902516 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2014;2014:902516. doi: 10.1155/2014/902516. 
      Epub 2014 Jul 7.