PMID- 25097734
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140806
LR  - 20211021
IS  - 2005-6419 (Print)
IS  - 2005-7563 (Electronic)
IS  - 2005-6419 (Linking)
VI  - 67
IP  - 1
DP  - 2014 Jul
TI  - Effect of pneumoperitoneum on the recovery from intense neuromuscular blockade by 
      rocuronium in healthy patients undergoing laparoscopic surgery.
PG  - 20-5
LID - 10.4097/kjae.2014.67.1.20 [doi]
AB  - BACKGROUND: This study investigated the effect of pneumoperitoneum on the 
      recovery from intense neuromuscular blockade by rocuronium in healthy patients 
      undergoing laparoscopic abdominal surgery. METHODS: Thirty adult patients 
      undergoing laparoscopic abdominal surgery were studied. Anesthesia was induced 
      with 1.5 mg/kg of propofol, 12 ug/kg of alfentanil and 0.6 mg/kg of rocuronium 
      and maintained with 2 vol% of sevoflurane and 0.05-0.2 microg/kg/min remifentanil. 
      The neuromuscular relaxation was monitored by Train-of-Four (TOF) and 
      post-tetanic count (PTC). Additional rocuronium of 0.2 mg/kg was administered for 
      deep neuromuscular blockade at 30 min after pneumoperitoneum. Before (PPpre) and 
      30 min after pneumoperitoneum (PPpost), PTC was measured at 6 min intervals. The 
      relationship between PTC and the time interval to reappearance of T1 response was 
      observed. RESULTS: The mean +/- SD of the intervals between the detection of 4 
      counts of the PTC and the first response to TOF stimulation was 13.0 +/- 1.1 min 
      and 16.4 +/- 6.3 min PPpre and PPpost, respectively (P = 0.20). There were 
      significant negative relationships between PTC observed and the time interval to 
      reappearance of T1 response (adjusted R(2) = 0.869, P < 0.001 for PPpre data, and 
      adjusted R(2) = 0.561, P < 0.001 for PPpost data). Comparing the difference of 
      regression equation between PPpre and PPpost data using a parallelism test, there 
      was no statistically significant difference (P = 0.193). CONCLUSIONS: This study 
      showed that PP with intra-abdominal pressure at the level of 13-14 mmHg did not 
      affect the recovery from intense neuromuscular blockade by rocuronium in healthy 
      patients undergoing laparoscopic abdominal surgery.
FAU - Kim, Hong Soon
AU  - Kim HS
AD  - Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and 
      Science, Incheon, Korea.
FAU - Lee, Dong Chul
AU  - Lee DC
AD  - Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and 
      Science, Incheon, Korea.
FAU - Lee, Mi Geum
AU  - Lee MG
AD  - Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and 
      Science, Incheon, Korea.
FAU - Son, Woon Rak
AU  - Son WR
AD  - Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and 
      Science, Incheon, Korea.
FAU - Kim, Yong Beom
AU  - Kim YB
AD  - Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and 
      Science, Incheon, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140729
PL  - Korea (South)
TA  - Korean J Anesthesiol
JT  - Korean journal of anesthesiology
JID - 101502451
PMC - PMC4121489
OTO - NOTNLM
OT  - Neuromuscular blockade
OT  - Neuromuscular monitoring
OT  - Pneumoperitoneum
OT  - Rocuronium
EDAT- 2014/08/07 06:00
MHDA- 2014/08/07 06:01
PMCR- 2014/07/01
CRDT- 2014/08/07 06:00
PHST- 2013/10/23 00:00 [received]
PHST- 2013/11/25 00:00 [revised]
PHST- 2013/12/09 00:00 [accepted]
PHST- 2014/08/07 06:00 [entrez]
PHST- 2014/08/07 06:00 [pubmed]
PHST- 2014/08/07 06:01 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - 10.4097/kjae.2014.67.1.20 [doi]
PST - ppublish
SO  - Korean J Anesthesiol. 2014 Jul;67(1):20-5. doi: 10.4097/kjae.2014.67.1.20. Epub 
      2014 Jul 29.