PMID- 25098834
OWN - NLM
STAT- MEDLINE
DCOM- 20150324
LR  - 20211021
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Print)
IS  - 0160-6689 (Linking)
VI  - 76
IP  - 1
DP  - 2015 Jan
TI  - Appetite regulatory hormones in women with anorexia nervosa: binge-eating/purging 
      versus restricting type.
PG  - 19-24
LID - 10.4088/JCP.13m08753 [doi]
AB  - OBJECTIVE: Anorexia nervosa is a psychiatric illness characterized by low weight, 
      disordered eating, and hallmark neuroendocrine dysfunction. Behavioral phenotypes 
      are defined by predominant restriction or bingeing/purging; binge-eating/purging 
      type anorexia nervosa is associated with poorer outcome. The pathophysiology 
      underlying anorexia nervosa types is unknown, but altered hormones, known to be 
      involved in eating behaviors, may play a role. METHOD: To examine the role of 
      anorexigenic hormones in anorexia nervosa subtypes, we examined serum levels of 
      peptide YY (PYY; total and active [3-36] forms), brain-derived neurotrophic 
      factor (BDNF), and leptin as primary outcomes in women with DSM-5 restricting 
      type anorexia nervosa (n = 50), binge-eating/purging type anorexia nervosa (n = 
      25), and healthy controls (n = 22). In addition, women completed validated 
      secondary outcome measures of eating disorder psychopathology (Eating Disorder 
      Examination-Questionnaire) and depression and anxiety symptoms (Hamilton Rating 
      Scales for Depression [HDRS] and Anxiety [HARS]). The study samples were 
      collected from May 22, 2004, to February 7, 2012. RESULTS: Mean PYY 3-36 and 
      leptin levels were lower and BDNF levels higher in binge-eating/purging type 
      anorexia nervosa than in restricting type anorexia nervosa (all P values < .05). 
      After controlling for body mass index, differences in PYY and PYY 3-36 between 
      anorexia nervosa types were significant (P < .05) and differences in BDNF were at 
      the trend level (P < .10). PYY 3-36 was positively (r = 0.27, P = .02) and leptin 
      was negatively (r = -0.51, P < .0001) associated with dietary restraint; BDNF was 
      positively associated with frequency of purging (r = 0.21, P = .04); and leptin 
      was negatively associated with frequency of bingeing (r = -0.29, P = .007) and 
      purging (r = -0.31, P = .004). CONCLUSIONS: Among women with anorexia nervosa, 
      the anorexigenic hormones PYY, BDNF, and leptin are differentially regulated 
      between the restricting and binge/purge types. Whether these hormone pathways 
      play etiologic roles with regard to anorexia nervosa behavioral types or are 
      compensatory merits further study.
CI  - (c) Copyright 2015 Physicians Postgraduate Press, Inc.
FAU - Eddy, Kamryn T
AU  - Eddy KT
AD  - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, 
      Department of Psychiatry, Harvard Medical School, 2 Longfellow Pl, Ste 200, 
      Boston, MA 02114 keddy@mgh.harvard.edu.
FAU - Lawson, Elizabeth A
AU  - Lawson EA
FAU - Meade, Christina
AU  - Meade C
FAU - Meenaghan, Erinne
AU  - Meenaghan E
FAU - Horton, Sarah E
AU  - Horton SE
FAU - Misra, Madhusmita
AU  - Misra M
FAU - Klibanski, Anne
AU  - Klibanski A
FAU - Miller, Karen K
AU  - Miller KK
LA  - eng
GR  - R01 DK052625/DK/NIDDK NIH HHS/United States
GR  - R01 MH083657/MH/NIMH NIH HHS/United States
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
GR  - P30 DK040561/DK/NIDDK NIH HHS/United States
GR  - K24 HL092902/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Leptin)
RN  - 106388-42-5 (Peptide YY)
SB  - IM
MH  - Adult
MH  - Anorexia Nervosa/*blood/classification/epidemiology
MH  - Appetite/physiology
MH  - Binge-Eating Disorder/*blood/epidemiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Leptin/*blood
MH  - Peptide YY/*blood
MH  - Young Adult
PMC - PMC4408926
MID - NIHMS681189
EDAT- 2014/08/08 06:00
MHDA- 2015/03/25 06:00
PMCR- 2016/01/01
CRDT- 2014/08/08 06:00
PHST- 2013/08/22 00:00 [received]
PHST- 2014/02/04 00:00 [accepted]
PHST- 2014/08/08 06:00 [entrez]
PHST- 2014/08/08 06:00 [pubmed]
PHST- 2015/03/25 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.4088/JCP.13m08753 [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2015 Jan;76(1):19-24. doi: 10.4088/JCP.13m08753.