PMID- 25099539
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20140815
IS  - 1521-186X (Electronic)
IS  - 0197-8462 (Linking)
VI  - 35
IP  - 6
DP  - 2014 Sep
TI  - Impact of 60-GHz millimeter waves and corresponding heat effect on endoplasmic 
      reticulum stress sensor gene expression.
PG  - 444-51
LID - 10.1002/bem.21864 [doi]
AB  - Emerging high data rate wireless communication systems, currently under 
      development, will operate at millimeter waves (MMW) and specifically in the 
      60 GHz band for broadband short-range communications. The aim of this study was 
      to investigate potential effects of MMW radiation on the cellular endoplasmic 
      reticulum (ER) stress. Human skin cell lines were exposed at 60.4 GHz, with 
      incident power densities (IPD) ranging between 1 and 20 mW/cm(2) . The upper IPD 
      limits correspond to the ICNIRP local exposure limit for the general public. The 
      expression of ER-stress sensors, namely BIP and ORP150, was then examined by 
      real-time RT-PCR. Our experimental data demonstrated that MMW radiations do not 
      change BIP or ORP150 mRNA basal levels, whatever the cell line, the exposure 
      duration or the IPD level. Co-exposure to the well-known ER-stress inducer 
      thapsigargin (TG) and MMW were then assessed. Our results show that MMW exposure 
      at 20 mW/cm(2) inhibits TG-induced BIP and ORP150 over expression. Experimental 
      controls showed that this inhibition is linked to the thermal effect resulting 
      from the MMW exposure.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Le Quement, Catherine
AU  - Le Quement C
AD  - Transcription, Environment and Cancer Group, Institute of Research in 
      Environmental and Occupational Health-IRSET, INSERM, University of Rennes 1, 
      Rennes, France.
FAU - Nicolaz, Christophe Nicolas
AU  - Nicolaz CN
FAU - Habauzit, Denis
AU  - Habauzit D
FAU - Zhadobov, Maxim
AU  - Zhadobov M
FAU - Sauleau, Ronan
AU  - Sauleau R
FAU - Le Drean, Yves
AU  - Le Drean Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140806
PL  - United States
TA  - Bioelectromagnetics
JT  - Bioelectromagnetics
JID - 8008281
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (oxygen-regulated proteins)
RN  - 67526-95-8 (Thapsigargin)
SB  - IM
MH  - Cell Line
MH  - *Electromagnetic Radiation
MH  - Endoplasmic Reticulum Stress/drug effects/*genetics/physiology/*radiation effects
MH  - Enzyme Inhibitors/pharmacology
MH  - Gene Expression/drug effects/physiology/radiation effects
MH  - HSP70 Heat-Shock Proteins/metabolism
MH  - *Hot Temperature
MH  - Humans
MH  - RNA, Messenger/metabolism
MH  - Real-Time Polymerase Chain Reaction
MH  - Skin/drug effects/radiation effects
MH  - Skin Physiological Phenomena/drug effects/genetics/radiation effects
MH  - Thapsigargin/pharmacology
MH  - Time Factors
MH  - Wireless Technology
OTO - NOTNLM
OT  - 60-GHz band
OT  - BIP
OT  - ORP-150
OT  - biological effects
OT  - keratinocytes
OT  - millimeter waves
EDAT- 2014/08/08 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/08/08 06:00
PHST- 2013/12/06 00:00 [received]
PHST- 2014/05/17 00:00 [accepted]
PHST- 2014/08/08 06:00 [entrez]
PHST- 2014/08/08 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1002/bem.21864 [doi]
PST - ppublish
SO  - Bioelectromagnetics. 2014 Sep;35(6):444-51. doi: 10.1002/bem.21864. Epub 2014 Aug 
      6.