PMID- 25100137
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20140829
IS  - 1860-7187 (Electronic)
IS  - 1860-7179 (Linking)
VI  - 9
IP  - 9
DP  - 2014 Sep
TI  - The design of RNA binders: targeting the HIV replication cycle as a case study.
PG  - 1982-96
LID - 10.1002/cmdc.201402259 [doi]
AB  - The human immunodeficiency virus 1 (HIV-1) replication cycle is finely tuned with 
      many important steps involving RNA-RNA or protein-RNA interactions, all of them 
      being potential targets for the development of new antiviral compounds. This 
      cycle can also be considered as a good benchmark for the evaluation of 
      early-stage strategies aiming at designing drugs that bind to RNA, with the 
      possibility to correlate in vitro activities with antiviral properties. In this 
      review, we highlight different approaches developed to interfere with four 
      important steps of the HIV-1 replication cycle: the early stage of reverse 
      transcription, the transactivation of viral transcription, the nuclear export of 
      partially spliced transcripts and the dimerization step.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Blond, Aurelie
AU  - Blond A
AD  - Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601, 
      CNRS, Universite Paris Descartes, Sorbonne Paris Cite, Faculte des Sciences 
      Fondamentales et Biomedicales, 45 Rue des Saints Peres, 75006 Paris (France).
FAU - Ennifar, Eric
AU  - Ennifar E
FAU - Tisne, Carine
AU  - Tisne C
FAU - Micouin, Laurent
AU  - Micouin L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140805
PL  - Germany
TA  - ChemMedChem
JT  - ChemMedChem
JID - 101259013
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Antiviral Agents)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Anti-HIV Agents/*pharmacology
MH  - Antiviral Agents/*pharmacology
MH  - Drug Design
MH  - Humans
MH  - Models, Molecular
MH  - RNA, Viral/*drug effects
OTO - NOTNLM
OT  - RNA recognition
OT  - antiviral agents
OT  - drug design
OT  - human immunodeficiency virus
OT  - new targets
EDAT- 2014/08/08 06:00
MHDA- 2015/05/15 06:00
CRDT- 2014/08/08 06:00
PHST- 2014/06/23 00:00 [received]
PHST- 2014/08/08 06:00 [entrez]
PHST- 2014/08/08 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - 10.1002/cmdc.201402259 [doi]
PST - ppublish
SO  - ChemMedChem. 2014 Sep;9(9):1982-96. doi: 10.1002/cmdc.201402259. Epub 2014 Aug 5.