PMID- 25100609
OWN - NLM
STAT- MEDLINE
DCOM- 20141003
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 34
IP  - 32
DP  - 2014 Aug 6
TI  - Low-intensity repetitive transcranial magnetic stimulation improves abnormal 
      visual cortical circuit topography and upregulates BDNF in mice.
PG  - 10780-92
LID - 10.1523/JNEUROSCI.0723-14.2014 [doi]
AB  - Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a 
      treatment for neurological and psychiatric disorders. Although the induced field 
      is focused on a target region during rTMS, adjacent areas also receive 
      stimulation at a lower intensity and the contribution of this perifocal 
      stimulation to network-wide effects is poorly defined. Here, we examined 
      low-intensity rTMS (LI-rTMS)-induced changes on a model neural network using the 
      visual systems of normal (C57Bl/6J wild-type, n = 22) and ephrin-A2A5(-/-) (n = 
      22) mice, the latter possessing visuotopic anomalies. Mice were treated with 
      LI-rTMS or sham (handling control) daily for 14 d, then fluorojade and fluororuby 
      were injected into visual cortex. The distribution of dorsal LGN (dLGN) neurons 
      and corticotectal terminal zones (TZs) was mapped and disorder defined by 
      comparing their actual location with that predicted by injection sites. In the 
      afferent geniculocortical projection, LI-rTMS decreased the abnormally high 
      dispersion of retrogradely labeled neurons in the dLGN of ephrin-A2A5(-/-) mice, 
      indicating geniculocortical map refinement. In the corticotectal efferents, 
      LI-rTMS improved topography of the most abnormal TZs in ephrin-A2A5(-/-) mice 
      without altering topographically normal TZs. To investigate a possible molecular 
      mechanism for LI-rTMS-induced structural plasticity, we measured brain derived 
      neurotrophic factor (BDNF) in the visual cortex and superior colliculus after 
      single and multiple stimulations. BDNF was upregulated after a single stimulation 
      for all groups, but only sustained in the superior colliculus of ephrin-A2A5(-/-) 
      mice. Our results show that LI-rTMS upregulates BDNF, promoting a plastic 
      environment conducive to beneficial reorganization of abnormal cortical circuits, 
      information that has important implications for clinical rTMS.
CI  - Copyright (c) 2014 the authors 0270-6474/14/3410780-13$15.00/0.
FAU - Makowiecki, Kalina
AU  - Makowiecki K
AD  - Experimental and Regenerative Neuroscience, School of Animal Biology, and.
FAU - Harvey, Alan R
AU  - Harvey AR
AD  - Experimental and Regenerative Neuroscience, School of Animal Biology, and School 
      of Anatomy, Physiology and Human Biology, The University of Western Australia, 
      Crawley, Western Australia 6009, and.
FAU - Sherrard, Rachel M
AU  - Sherrard RM
AD  - Sorbonne Universites, Pierre and Marie Curie University of Paris 06 and Centre 
      National de la Recherche Scientifique, Institut de Biologie Paris Seine, UMR8256 
      Biological Adaptation and Ageing, F-75005 Paris, France.
FAU - Rodger, Jennifer
AU  - Rodger J
AD  - Experimental and Regenerative Neuroscience, School of Animal Biology, and 
      jennifer.rodger@uwa.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ephrin-A2)
RN  - 0 (Ephrin-A5)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Biophysics
MH  - *Brain Diseases/genetics/pathology/therapy
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Ephrin-A2/deficiency/genetics
MH  - Ephrin-A5/deficiency/genetics
MH  - Geniculate Bodies/abnormalities/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neural Pathways/abnormalities/pathology
MH  - RNA, Messenger/metabolism
MH  - *Transcranial Magnetic Stimulation
MH  - Up-Regulation/genetics/*physiology
MH  - Visual Cortex/*abnormalities
PMC - PMC4122806
OTO - NOTNLM
OT  - LI-rTMS
OT  - corticotectal projection
OT  - critical period
OT  - ephrin-A2A5-/- mice
OT  - geniculocortical
OT  - plasticity
EDAT- 2014/08/08 06:00
MHDA- 2014/10/04 06:00
PMCR- 2015/02/06
CRDT- 2014/08/08 06:00
PHST- 2014/08/08 06:00 [entrez]
PHST- 2014/08/08 06:00 [pubmed]
PHST- 2014/10/04 06:00 [medline]
PHST- 2015/02/06 00:00 [pmc-release]
AID - 34/32/10780 [pii]
AID - 0723-14 [pii]
AID - 10.1523/JNEUROSCI.0723-14.2014 [doi]
PST - ppublish
SO  - J Neurosci. 2014 Aug 6;34(32):10780-92. doi: 10.1523/JNEUROSCI.0723-14.2014.