PMID- 25101323
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220331
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2014
DP  - 2014
TI  - Differences of various region-of-interest methods for measuring dopamine 
      transporter availability using 99mTc-TRODAT-1 SPECT.
PG  - 837439
LID - 10.1155/2014/837439 [doi]
LID - 837439
AB  - This study was to investigate whether various region-of-interest (ROI) methods 
      for measuring dopamine transporter (DAT) availabilities by single photon emission 
      computed tomography (SPECT) are statistically different, whether results of 
      medical research are thereby influenced, and causes of these differences. 
      Eighty-four healthy adults with (99m)Tc-TRODAT-1 SPECT and magnetic resonance 
      imaging (MRI) scans were included. Six major analysis approaches were compared: 
      (1) ROI drawn on the coregistered MRI; (2) ROIs drawn on the SPECT images; (3) 
      standard ROI templates; (4) threshold-ROIs; (5) atlas-based mappings with 
      coregistered MRI; and (6) atlas-based mappings with SPECT images. Using the 
      atlas-based approaches we assessed the influence of striatum ROIs by slice-wise 
      and voxel-wise comparisons. In (5) and (6), three partial-volume correction (PVC) 
      methods were also explored. The results showed that DAT availabilities obtained 
      from different methods were closely related but quite different and leaded to 
      significant differences in determining the declines of DAT availability per 
      decade (range: 5.95-11.99%). Use of 3D whole-striatum or more transverse slices 
      could avoid biases in measuring the striatal DAT declines per decade. Atlas-based 
      methods with PVC may be the preferable methods for medical research.
FAU - Yin, Tang-Kai
AU  - Yin TK
AD  - Department of Computer Science and Information Engineering, National University 
      of Kaohsiung, 700 Kaohsiung University Road, Kaohsiung 811, Taiwan.
FAU - Lee, Bi-Fang
AU  - Lee BF
AD  - Department of Nuclear Medicine, National Cheng Kung University Hospital, College 
      of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
FAU - Yang, Yen Kuang
AU  - Yang YK
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan 704, Taiwan.
FAU - Chiu, Nan-Tsing
AU  - Chiu NT
AD  - Department of Nuclear Medicine, National Cheng Kung University Hospital, College 
      of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140701
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 7440-26-8 (Technetium)
SB  - IM
MH  - Adult
MH  - Dopamine Plasma Membrane Transport Proteins/*analysis
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Technetium
MH  - Tomography, Emission-Computed, Single-Photon/*methods
MH  - Young Adult
PMC - PMC4102026
EDAT- 2014/08/08 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/07/01
CRDT- 2014/08/08 06:00
PHST- 2014/02/01 00:00 [received]
PHST- 2014/06/04 00:00 [accepted]
PHST- 2014/08/08 06:00 [entrez]
PHST- 2014/08/08 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - 10.1155/2014/837439 [doi]
PST - ppublish
SO  - ScientificWorldJournal. 2014;2014:837439. doi: 10.1155/2014/837439. Epub 2014 Jul 
      1.