PMID- 25101961
OWN - NLM
STAT- MEDLINE
DCOM- 20151130
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 8
DP  - 2014
TI  - Moderate-vigorous physical activity across body mass index in females: moderating 
      effect of endocannabinoids and temperament.
PG  - e104534
LID - 10.1371/journal.pone.0104534 [doi]
LID - e104534
AB  - BACKGROUND: Endocannabinoids and temperament traits have been linked to both 
      physical activity and body mass index (BMI) however no study has explored how 
      these factors interact in females. The aims of this cross-sectional study were to 
      1) examine differences among distinct BMI groups on daytime physical activity and 
      time spent in moderate-vigorous physical activity (MVPA), temperament traits and 
      plasma endocannabinoid concentrations; and 2) explore the association and 
      interaction between MVPA, temperament, endocannabinoids and BMI. METHODS: 
      Physical activity was measured with the wrist-worn accelerometer Actiwatch AW7, 
      in a sample of 189 female participants (43 morbid obese, 30 obese, and 116 
      healthy-weight controls). The Temperament and Character Inventory-Revised 
      questionnaire was used to assess personality traits. BMI was calculated by 
      bioelectrical impedance analysis via the TANITA digital scale. Blood analyses 
      were conducted to measure levels of endocannabinoids and endocannabinoid-related 
      compounds. Path-analysis was performed to examine the association between 
      predictive variables and MVPA. RESULTS: Obese groups showed lower MVPA and 
      dysfunctional temperament traits compared to healthy-weight controls. Plasma 
      concentrations of 2-arachidonoylglyceryl (2-AG) were greater in obese groups. 
      Path-analysis identified a direct effect between greater MVPA and low BMI 
      (b = -0.13, p = .039) and high MVPA levels were associated with elevated 
      anandamide (AEA) levels (b = 0.16, p = .049) and N-oleylethanolamide (OEA) levels 
      (b = 0.22, p = .004), as well as high Novelty seeking (b = 0.18, p<.001) and low 
      Harm avoidance (b = -0.16, p<.001). CONCLUSIONS: Obese individuals showed a 
      distinct temperament profile and circulating endocannabinoids compared to 
      controls. Temperament and endocannabinoids may act as moderators of the low MVPA 
      in obesity.
FAU - Fernandez-Aranda, Fernando
AU  - Fernandez-Aranda F
AD  - Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, 
      Spain; CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud 
      Carlos III, Madrid, Spain; Department of Clinical Sciences, School of Medicine, 
      University of Barcelona, Barcelona, Spain.
FAU - Sauchelli, Sarah
AU  - Sauchelli S
AD  - Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, 
      Spain.
FAU - Pastor, Antoni
AU  - Pastor A
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Department of Pharmacology, School of Medicine, Universitat 
      Autonoma de Barcelona, Barcelona, Spain; Human Pharmacology and Clinical 
      Neurosciences Research Group, Neuroscience Research Program, IMIM (Hospital del 
      Mar Medical Research Institute), Barcelona, Spain.
FAU - Gonzalez, Marcela L
AU  - Gonzalez ML
AD  - Department of Psychology, Universitat Rovira i Virgili, Tarragona, Spain.
FAU - de la Torre, Rafael
AU  - de la Torre R
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Human Pharmacology and Clinical Neurosciences Research Group, 
      Neuroscience Research Program, IMIM (Hospital del Mar Medical Research 
      Institute), Barcelona, Spain; Department of Experimental and Health Sciences, 
      Universitat Pompeu Fabra, Barcelona, Spain.
FAU - Granero, Roser
AU  - Granero R
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Departament de Psicobiologia i Metodologia, Universitat Autonoma 
      de Barcelona, Barcelona, Spain.
FAU - Jimenez-Murcia, Susana
AU  - Jimenez-Murcia S
AD  - Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, 
      Spain; CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud 
      Carlos III, Madrid, Spain; Department of Clinical Sciences, School of Medicine, 
      University of Barcelona, Barcelona, Spain.
FAU - Banos, Rosa
AU  - Banos R
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Department of Psychological, Personality, Evaluation and Treatment 
      of the University of Valencia, Valencia, Spain.
FAU - Botella, Cristina
AU  - Botella C
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Department of Basic Psychology, Clinic and Psychobiology of the 
      University Jaume I, Castello, Spain.
FAU - Fernandez-Real, Jose M
AU  - Fernandez-Real JM
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Department of Diabetes, Endocrinology and Nutrition, Institut 
      d'Investigacio Biomedica de Girona (IdlBGi) Hospital Dr Josep Trueta, Girona, 
      Spain.
FAU - Fernandez-Garcia, Jose C
AU  - Fernandez-Garcia JC
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Department of Diabetes, Endocrinology and Nutrition, Hospital 
      Clinico Universitario Virgen de Victoria, Malaga, Spain.
FAU - Fruhbeck, Gema
AU  - Fruhbeck G
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Department of Endocrinology and Nutrition, Clinica Universidad de 
      Navarra, University of Navarra, Pamplona, Spain.
FAU - Gomez-Ambrosi, Javier
AU  - Gomez-Ambrosi J
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Department of Endocrinology and Nutrition, Clinica Universidad de 
      Navarra, University of Navarra, Pamplona, Spain.
FAU - Rodriguez, Roser
AU  - Rodriguez R
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Department of Diabetes, Endocrinology and Nutrition, Institut 
      d'Investigacio Biomedica de Girona (IdlBGi) Hospital Dr Josep Trueta, Girona, 
      Spain.
FAU - Tinahones, Francisco J
AU  - Tinahones FJ
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Department of Diabetes, Endocrinology and Nutrition, Hospital 
      Clinico Universitario Virgen de Victoria, Malaga, Spain.
FAU - Arcelus, Jon
AU  - Arcelus J
AD  - Eating Disorders Service, Glenfield University Hospital, Leicester, United 
      Kingdom.
FAU - Fagundo, Ana B
AU  - Fagundo AB
AD  - Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, 
      Spain; CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud 
      Carlos III, Madrid, Spain.
FAU - Aguera, Zaida
AU  - Aguera Z
AD  - Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, 
      Spain; CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud 
      Carlos III, Madrid, Spain.
FAU - Miro, Jordi
AU  - Miro J
AD  - Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 
      Barcelona, Spain.
FAU - Casanueva, Felipe F
AU  - Casanueva FF
AD  - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, 
      Madrid, Spain; Department of Medicine, Endocrinology Division, Santiago de 
      Compostela University, Complejo Hospitalario Universitario, Santiago de 
      Compostela, Spain.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140807
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Endocannabinoids)
SB  - IM
MH  - Adult
MH  - *Body Mass Index
MH  - Endocannabinoids/*blood
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Motor Activity
MH  - Obesity/*blood/*physiopathology
MH  - *Temperament
PMC - PMC4125187
COIS- Competing Interests: Co-author Dr. Susana Jimenez-Murcia is currently an Academic 
      Editor for this journal. However this does not alter the authors' adherence to 
      PLOS ONE Editorial policies on sharing data and materials and criteria.
EDAT- 2014/08/08 06:00
MHDA- 2015/12/15 06:00
PMCR- 2014/08/07
CRDT- 2014/08/08 06:00
PHST- 2014/03/07 00:00 [received]
PHST- 2014/07/10 00:00 [accepted]
PHST- 2014/08/08 06:00 [entrez]
PHST- 2014/08/08 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2014/08/07 00:00 [pmc-release]
AID - PONE-D-14-10358 [pii]
AID - 10.1371/journal.pone.0104534 [doi]
PST - epublish
SO  - PLoS One. 2014 Aug 7;9(8):e104534. doi: 10.1371/journal.pone.0104534. eCollection 
      2014.