PMID- 25102002
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20140913
IS  - 1534-7796 (Electronic)
IS  - 0033-3174 (Linking)
VI  - 76
IP  - 7
DP  - 2014 Sep
TI  - Job strain as a risk factor for the onset of type 2 diabetes mellitus: findings 
      from the MONICA/KORA Augsburg cohort study.
PG  - 562-8
LID - 10.1097/PSY.0000000000000084 [doi]
AB  - OBJECTIVE: To examine whether job strain is associated with an increased risk of 
      subsequent Type 2 diabetes mellitus (T2DM) development in a population-based 
      study of men and women. METHODS: Data were derived from the prospective 
      MONICA/KORA Augsburg study. We investigated 5337 working participants aged 29 to 
      66 years without diabetes at one of the three baseline surveys. Job strain was 
      measured by the Karasek job content questionnaire. High job strain was defined by 
      the quadrant approach, where high job demands combined with low job control were 
      classified as high job strain. Continuous job strain (quotient of job demands 
      divided by job control) was additionally analyzed as sensitivity analysis. Hazard 
      ratios (HRs) were estimated using multivariable Cox proportional hazards models 
      with adjustment for age, sex, survey, socioeconomic and life-style variables, 
      parental history of diabetes, and body mass index. RESULTS: During a median 
      follow-up of 12.7 years, 291 incident cases of T2DM were observed. The 
      participants with high job strain at baseline had a 45% higher fully adjusted 
      risk to develop T2DM than did those with low job strain (HR = 1.45 [95% 
      confidence interval = 1.00-2.10], p = .048). On the continuous scale, more severe 
      job strain in the magnitude of 1 standard deviation corresponded to a 12% 
      increased fully adjusted T2DM risk (HR = 1.12 [95% confidence interval = 
      1.00-1.25], p = .045). CONCLUSIONS: Men and women who experience high job strain 
      are at higher risk for developing T2DM independently of traditional risk factors. 
      Preventive strategies to combat the globally increasing T2DM epidemic should take 
      into consideration the adverse effects of high strain in the work environment.
FAU - Huth, Cornelia
AU  - Huth C
AD  - From the Institute of Epidemiology II (C.H., B.T., J.B., R.T.E., A.S., C.M., 
      K.-H.L), Helmholtz Zentrum Munchen, German Research Center for Environmental 
      Health (GmbH), Helmholtz Zentrum Munchen, Neuherberg, Germany; German Center for 
      Diabetes Research (DZD) (C.H., B.T., A.S., C.M.), Neuherberg, Germany; Department 
      of Psychosomatic Medicine and Psychotherapy (J.K.), University of Giessen, Giessen, 
      Germany; Department of Psychosomatic Medicine and Psychotherapy (J.K.), 
      University of Marburg, Marburg, Germany; MONICA/KORA Myocardial Infarction 
      Registry (C.M.), Central Hospital of Augsburg, Augsburg, Germany; and Department 
      of Psychosomatic Medicine and Psychotherapy (K.-H.L.), Klinikum Rechts der Isar, 
      Technische Universitat Munchen (TUM), Munich, Germany.
FAU - Thorand, Barbara
AU  - Thorand B
FAU - Baumert, Jens
AU  - Baumert J
FAU - Kruse, Johannes
AU  - Kruse J
FAU - Emeny, Rebecca Thwing
AU  - Emeny RT
FAU - Schneider, Andrea
AU  - Schneider A
FAU - Meisinger, Christa
AU  - Meisinger C
FAU - Ladwig, Karl-Heinz
AU  - Ladwig KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Psychosom Med
JT  - Psychosomatic medicine
JID - 0376505
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*etiology/psychology
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/*complications/psychology
MH  - Prospective Studies
MH  - Risk Factors
MH  - Stress, Psychological/*complications
EDAT- 2014/08/08 06:00
MHDA- 2015/06/24 06:00
CRDT- 2014/08/08 06:00
PHST- 2014/08/08 06:00 [entrez]
PHST- 2014/08/08 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - 10.1097/PSY.0000000000000084 [doi]
PST - ppublish
SO  - Psychosom Med. 2014 Sep;76(7):562-8. doi: 10.1097/PSY.0000000000000084.