PMID- 25102071
OWN - NLM
STAT- MEDLINE
DCOM- 20150715
LR  - 20221207
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 438
DP  - 2015 Jan 1
TI  - Body mass index negatively regulates glycated albumin through insulin secretion 
      in patients with type 2 diabetes mellitus.
PG  - 19-23
LID - S0009-8981(14)00331-3 [pii]
LID - 10.1016/j.cca.2014.07.035 [doi]
AB  - BACKGROUND: Glycated albumin (GA) is known to be negatively regulated by body 
      mass index (BMI) in non-diabetic subjects and patients with type 2 diabetes 
      mellitus (T2DM). In non-diabetic subjects, a mechanism has been proposed in which 
      chronic inflammation associated with obesity increases albumin metabolism and 
      negatively regulates GA levels. However, whether this same mechanism exists in 
      T2DM is unclear. We investigated the factor(s) which influence GA levels in T2DM 
      patients. METHODS: This study included 179 T2DM patients from among people 
      undergoing complete medical examinations. Correlations between GA and the 
      following variables were examined among fasting samples for T2DM patients: BMI, 
      C-reactive protein (CRP), homeostasis model assessment for beta-cell function 
      (HOMA-beta) and homeostasis model assessment for insulin resistance (HOMA-R). 
      RESULTS: BMI was significantly positively correlated with CRP, but CRP was not 
      significantly correlated with GA. HOMA-beta was significantly positively correlated 
      with BMI and significantly negatively correlated with GA. Multivariate analysis 
      showed that HOMA-beta was a significant explanatory variable for GA, but not CRP and 
      HOMA-R. CONCLUSIONS: Our findings suggest that insulin secretion plays a greater 
      role than chronic inflammation in the mechanism by which BMI negatively regulates 
      GA in T2DM patients.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Koga, Masafumi
AU  - Koga M
AD  - Department of Internal Medicine, Kawanishi City Hospital, Hyogo, Japan. 
      Electronic address: m-koga@kawanishi-city-hospital.com.
FAU - Hirata, Takumi
AU  - Hirata T
AD  - Foundation for Biomedical Research and Innovation, Hyogo, Japan.
FAU - Kasayama, Soji
AU  - Kasayama S
AD  - Department of Medicine, Nissay Hospital, Osaka, Japan.
FAU - Ishizaka, Yuko
AU  - Ishizaka Y
AD  - Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, 
      Tokyo, Japan.
FAU - Yamakado, Minoru
AU  - Yamakado M
AD  - Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, 
      Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140804
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Insulin)
RN  - 0 (Serum Albumin)
RN  - 0 (Glycated Serum Albumin)
SB  - IM
MH  - Aged
MH  - *Body Mass Index
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Female
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin Secretion
MH  - Male
MH  - Middle Aged
MH  - Serum Albumin/*metabolism
MH  - Glycated Serum Albumin
OTO - NOTNLM
OT  - Body mass index
OT  - Glycated albumin
OT  - HbA1c
OT  - Insulin secretion
OT  - Type 2 diabetes mellitus
EDAT- 2014/08/08 06:00
MHDA- 2015/07/16 06:00
CRDT- 2014/08/08 06:00
PHST- 2014/01/24 00:00 [received]
PHST- 2014/07/08 00:00 [revised]
PHST- 2014/07/25 00:00 [accepted]
PHST- 2014/08/08 06:00 [entrez]
PHST- 2014/08/08 06:00 [pubmed]
PHST- 2015/07/16 06:00 [medline]
AID - S0009-8981(14)00331-3 [pii]
AID - 10.1016/j.cca.2014.07.035 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2015 Jan 1;438:19-23. doi: 10.1016/j.cca.2014.07.035. Epub 2014 
      Aug 4.