PMID- 25102683
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20191027
IS  - 0255-2922 (Print)
IS  - 0255-2922 (Linking)
VI  - 34
IP  - 1
DP  - 2014 Feb
TI  - Efficacy and safety of traditional Chinese medicine for the treatment of acquired 
      immunodeficiency syndrome: a systematic review.
PG  - 1-9
AB  - OBJECTIVE: To systematically review the efficacy and safety of Traditional 
      Chinese Medicine (TCM) interventions, compared with control interventions 
      (placebo or conventional Western medical therapy), in the treatment of acquired 
      immunodeficiency syndrome (AIDS). METHODS: Electronic databases including PubMed, 
      the Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang 
      Data were searched to identify relevant randomized controlled trials (RCTs) 
      published as of May 2012. Studies were selected according to the specified 
      inclusion and exclusion criteria and then subjected to methodological quality 
      assessment, data extraction, and meta-analysis according to the Cochrane Handbook 
      for Systematic Reviews of Interventions. RESULTS: Twelve RCTs involving 881 
      patients with AIDS were included. Methodological quality assessment showed that 
      two were high-quality, two were moderate-quality, and eight were low-quality. 
      Meta-analysis showed that TCM interventions were associated with significantly 
      reduced plasma viral load compared with placebo [odds ratio OR = 2.46, 95% 
      confidence interval CI (1.02, 5.94); P = 0.04]. However, the reductions in plasma 
      viral load significantly favored conventional Western medical therapy alone over 
      integrated traditional Chinese and Western medical therapy [OR = 0.16, 95% CI 
      (0.05, 0.55); P = 0.004]. Patients receiving TCM interventions had significantly 
      higher CD4+ T lymphocyte counts compared with those on placebo [OR = 2.54, 95% CI 
      (1.40, 4.60); P = 0.002]. In addition, TCM interventions were significantly more 
      likely to have improved clinical symptoms [OR = 2.82, 95% CI (1.85, 4.31); P < 
      0.00001]. TCM interventions conferred a similar risk of adverse events (AEs) 
      compared with control interventions [OR = 1.87, 95% CI (0.58, 6.01); P = 0.29]. 
      CONCLUSION: Current evidence suggests that TCM interventions are significantly 
      more effective than placebo in reducing plasma viral load and increasing CD4+ T 
      lymphocyte count in patients with AIDS. When compared with conventional Western 
      medical therapy, TCM interventions were significantly less effective in reducing 
      plasma viral load, although they were associated with a higher percentage of 
      patients with improved symptoms. Patients receiving TCM interventions did not 
      seem to be at an increased risk of AEs.
FAU - Deng, Xin
AU  - Deng X
FAU - Jiang, Manjun
AU  - Jiang M
FAU - Zhao, Xiaofang
AU  - Zhao X
FAU - Liang, Jian
AU  - Liang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - China
TA  - J Tradit Chin Med
JT  - Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
JID - 8211546
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*drug therapy/immunology/virology
MH  - CD4-Positive T-Lymphocytes/drug effects/immunology/virology
MH  - Clinical Trials as Topic
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - HIV-1/drug effects
MH  - Humans
MH  - Treatment Outcome
EDAT- 2014/08/12 06:00
MHDA- 2014/09/03 06:00
CRDT- 2014/08/09 06:00
PHST- 2014/08/09 06:00 [entrez]
PHST- 2014/08/12 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
AID - 10.1016/s0254-6272(14)60046-7 [doi]
PST - ppublish
SO  - J Tradit Chin Med. 2014 Feb;34(1):1-9. doi: 10.1016/s0254-6272(14)60046-7.