PMID- 25103087
OWN - NLM
STAT- MEDLINE
DCOM- 20150709
LR  - 20211021
IS  - 1749-5024 (Electronic)
IS  - 1749-5016 (Print)
IS  - 1749-5016 (Linking)
VI  - 10
IP  - 5
DP  - 2015 May
TI  - BDNFval66met affects neural activation pattern during fear conditioning and 24 h 
      delayed fear recall.
PG  - 664-71
LID - 10.1093/scan/nsu102 [doi]
AB  - Brain-derived neurotrophic factor (BDNF), the most abundant neutrophin in the 
      mammalian central nervous system, is critically involved in synaptic plasticity. 
      In both rodents and humans, BDNF has been implicated in hippocampus- and 
      amygdala-dependent learning and memory and has more recently been linked to fear 
      extinction processes. Fifty-nine healthy participants, genotyped for the 
      functional BDNFval66met polymorphism, underwent a fear conditioning and 
      24h-delayed extinction protocol while skin conductance and blood oxygenation 
      level dependent (BOLD) responses (functional magnetic resonance imaging) were 
      acquired. We present the first report of neural activation pattern during fear 
      acquisition 'and' extinction for the BDNFval66met polymorphism using a 
      differential conditioned stimulus (CS)+ > CS- comparison. During conditioning, we 
      observed heightened allele dose-dependent responses in the amygdala and reduced 
      responses in the subgenual anterior cingulate cortex in BDNFval66met 
      met-carriers. During early extinction, 24h later, we again observed heightened 
      responses in several regions ascribed to the fear network in met-carriers as 
      opposed to val-carriers (insula, amygdala, hippocampus), which likely reflects 
      fear memory recall. No differences were observed during late extinction, which 
      likely reflects learned extinction. Our data thus support previous associations 
      of the BDNFval66met polymorphism with neural activation in the fear and 
      extinction network, but speak against a specific association with fear extinction 
      processes.
CI  - (c) The Author (2014). Published by Oxford University Press. For Permissions, 
      please email: journals.permissions@oup.com.
FAU - Lonsdorf, Tina B
AU  - Lonsdorf TB
AD  - Institute for Systems Neuroscience, University Hospital Hamburg-Eppendorf, 
      Hamburg, Germany, Department of Clinical Neuroscience, Karolinska Institutet, 
      Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, Sweden, Department of 
      Molecular Medicine and Surgery, Neurogenetics Section, Karolinska Institutet, 
      Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University 
      Hospital, Solna, Sweden Institute for Systems Neuroscience, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany, Department of Clinical Neuroscience, 
      Karolinska Institutet, Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, 
      Sweden, Department of Molecular Medicine and Surgery, Neurogenetics Section, 
      Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, 
      Karolinska University Hospital, Solna, Sweden Institute for Systems Neuroscience, 
      University Hospital Hamburg-Eppendorf, Hamburg, Germany, Department of Clinical 
      Neuroscience, Karolinska Institutet, Stockholm, Sweden, Stockholm Brain 
      Institutet, Stockholm, Sweden, Department of Molecular Medicine and Surgery, 
      Neurogenetics Section, Karolinska Institutet, Stockholm, Sweden, and Center for 
      Molecular Medicine, Karolinska University Hospital, Solna, Sweden Institute for 
      Systems Neuroscience, University Hospital Hamburg-Eppendorf, Hamburg, Germany, 
      Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 
      Stockholm Brain Institutet, Stockholm, Sweden, Department of Molecular Medicine 
      and Surgery, Neurogenetics Section, Karolinska Institutet, Stockholm, Sweden, and 
      Center for Molecular Medicine, Karolinska University Hospital, Solna, Sweden 
      t.lonsdorf@uke.de.
FAU - Golkar, Armita
AU  - Golkar A
AD  - Institute for Systems Neuroscience, University Hospital Hamburg-Eppendorf, 
      Hamburg, Germany, Department of Clinical Neuroscience, Karolinska Institutet, 
      Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, Sweden, Department of 
      Molecular Medicine and Surgery, Neurogenetics Section, Karolinska Institutet, 
      Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University 
      Hospital, Solna, Sweden Institute for Systems Neuroscience, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany, Department of Clinical Neuroscience, 
      Karolinska Institutet, Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, 
      Sweden, Department of Molecular Medicine and Surgery, Neurogenetics Section, 
      Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, 
      Karolinska University Hospital, Solna, Sweden.
FAU - Lindstrom, Kara M
AU  - Lindstrom KM
AD  - Institute for Systems Neuroscience, University Hospital Hamburg-Eppendorf, 
      Hamburg, Germany, Department of Clinical Neuroscience, Karolinska Institutet, 
      Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, Sweden, Department of 
      Molecular Medicine and Surgery, Neurogenetics Section, Karolinska Institutet, 
      Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University 
      Hospital, Solna, Sweden.
FAU - Haaker, Jan
AU  - Haaker J
AD  - Institute for Systems Neuroscience, University Hospital Hamburg-Eppendorf, 
      Hamburg, Germany, Department of Clinical Neuroscience, Karolinska Institutet, 
      Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, Sweden, Department of 
      Molecular Medicine and Surgery, Neurogenetics Section, Karolinska Institutet, 
      Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University 
      Hospital, Solna, Sweden Institute for Systems Neuroscience, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany, Department of Clinical Neuroscience, 
      Karolinska Institutet, Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, 
      Sweden, Department of Molecular Medicine and Surgery, Neurogenetics Section, 
      Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, 
      Karolinska University Hospital, Solna, Sweden.
FAU - Ohman, Arne
AU  - Ohman A
AD  - Institute for Systems Neuroscience, University Hospital Hamburg-Eppendorf, 
      Hamburg, Germany, Department of Clinical Neuroscience, Karolinska Institutet, 
      Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, Sweden, Department of 
      Molecular Medicine and Surgery, Neurogenetics Section, Karolinska Institutet, 
      Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University 
      Hospital, Solna, Sweden Institute for Systems Neuroscience, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany, Department of Clinical Neuroscience, 
      Karolinska Institutet, Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, 
      Sweden, Department of Molecular Medicine and Surgery, Neurogenetics Section, 
      Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, 
      Karolinska University Hospital, Solna, Sweden.
FAU - Schalling, Martin
AU  - Schalling M
AD  - Institute for Systems Neuroscience, University Hospital Hamburg-Eppendorf, 
      Hamburg, Germany, Department of Clinical Neuroscience, Karolinska Institutet, 
      Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, Sweden, Department of 
      Molecular Medicine and Surgery, Neurogenetics Section, Karolinska Institutet, 
      Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University 
      Hospital, Solna, Sweden Institute for Systems Neuroscience, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany, Department of Clinical Neuroscience, 
      Karolinska Institutet, Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, 
      Sweden, Department of Molecular Medicine and Surgery, Neurogenetics Section, 
      Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, 
      Karolinska University Hospital, Solna, Sweden.
FAU - Ingvar, Martin
AU  - Ingvar M
AD  - Institute for Systems Neuroscience, University Hospital Hamburg-Eppendorf, 
      Hamburg, Germany, Department of Clinical Neuroscience, Karolinska Institutet, 
      Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, Sweden, Department of 
      Molecular Medicine and Surgery, Neurogenetics Section, Karolinska Institutet, 
      Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University 
      Hospital, Solna, Sweden Institute for Systems Neuroscience, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany, Department of Clinical Neuroscience, 
      Karolinska Institutet, Stockholm, Sweden, Stockholm Brain Institutet, Stockholm, 
      Sweden, Department of Molecular Medicine and Surgery, Neurogenetics Section, 
      Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, 
      Karolinska University Hospital, Solna, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140807
PL  - England
TA  - Soc Cogn Affect Neurosci
JT  - Social cognitive and affective neuroscience
JID - 101288795
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Anxiety/genetics/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics/*physiology
MH  - Conditioning, Psychological/*physiology
MH  - Extinction, Psychological/physiology
MH  - Fear/*physiology
MH  - Female
MH  - Galvanic Skin Response/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mental Recall/*physiology
MH  - Mutation/*genetics/*physiology
MH  - Oxygen/blood
MH  - Photic Stimulation
MH  - Polymorphism, Single Nucleotide
MH  - Young Adult
PMC - PMC4420743
OTO - NOTNLM
OT  - CBT
OT  - amygdala
OT  - anxiety
OT  - fear recall
OT  - therapygenetics
OT  - vmPFC
EDAT- 2014/08/12 06:00
MHDA- 2015/07/15 06:00
PMCR- 2016/05/01
CRDT- 2014/08/09 06:00
PHST- 2014/02/18 00:00 [received]
PHST- 2014/07/17 00:00 [accepted]
PHST- 2014/08/09 06:00 [entrez]
PHST- 2014/08/12 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - nsu102 [pii]
AID - 10.1093/scan/nsu102 [doi]
PST - ppublish
SO  - Soc Cogn Affect Neurosci. 2015 May;10(5):664-71. doi: 10.1093/scan/nsu102. Epub 
      2014 Aug 7.