PMID- 25103403 OWN - NLM STAT- MEDLINE DCOM- 20150914 LR - 20211021 IS - 1708-0428 (Electronic) IS - 0960-8923 (Print) IS - 0960-8923 (Linking) VI - 25 IP - 2 DP - 2015 Feb TI - Predictive factors of type 2 diabetes mellitus remission following bariatric surgery: a meta-analysis. PG - 199-208 LID - 10.1007/s11695-014-1391-y [doi] AB - BACKGROUND: Although a few studies have been reported on predictive factors of postoperative diabetes remission, the conclusions remain inconsistent. This meta-analysis aimed to assess the preoperative clinical factors for type 2 diabetes mellitus (T2DM) remission after bariatric surgery. METHODS: The Cochrane Library, PubMed, MEDLINE, Embase, and CINAHL databases were searched. All human studies published in English between 1 January 1992 and 1 September 2013 reporting on the parameters of interest were included. RESULTS: In total, 15 studies involving 1,753 bariatric surgery patients were selected. Analyses were performed separately for the parameters of interest. T2DM remission was observed to be negatively correlated with age, diabetes duration, insulin use, and HbA1c levels. Baseline body mass index (BMI) and C-peptide levels were positively associated with the remission rate in Asian patients. However, there was no significant association between gender and remission rate. CONCLUSIONS: Patients with younger age, short diabetes duration, better glucose control, and better beta cell function were more likely to achieve T2DM remission after bariatric surgery. However, further randomized controlled trials with uniform remission criteria should be conducted to provide more reliable evidence. FAU - Wang, Guo-Feng AU - Wang GF AD - Department of Endocrinology Medicine, Lianyungang First People's Hospital, Affiliated Hospital of Xuzhou Medical College, Tongguan North Road 182, Lianyungang City, Jiangsu Province, 222000, China, nfmwangguofeng@126.com. FAU - Yan, Yong-Xin AU - Yan YX FAU - Xu, Ning AU - Xu N FAU - Yin, Dong AU - Yin D FAU - Hui, Yuan AU - Hui Y FAU - Zhang, Ji-Ping AU - Zhang JP FAU - Han, Guan-Jun AU - Han GJ FAU - Ma, Ning AU - Ma N FAU - Wu, Yan AU - Wu Y FAU - Xu, Jing-Zi AU - Xu JZ FAU - Yang, Tao AU - Yang T LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 RN - 0 (Blood Glucose) SB - IM CIN - Obes Surg. 2015 Dec;25(12):2424-5. PMID: 26420762 MH - Adult MH - Age Factors MH - Bariatric Surgery MH - Blood Glucose/analysis MH - Diabetes Mellitus, Type 2/blood/*surgery MH - Female MH - Humans MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Remission Induction MH - Time Factors PMC - PMC4297287 COIS- The authors declare that no competing interests exist. EDAT- 2014/08/12 06:00 MHDA- 2015/09/15 06:00 PMCR- 2014/08/08 CRDT- 2014/08/09 06:00 PHST- 2014/08/09 06:00 [entrez] PHST- 2014/08/12 06:00 [pubmed] PHST- 2015/09/15 06:00 [medline] PHST- 2014/08/08 00:00 [pmc-release] AID - 1391 [pii] AID - 10.1007/s11695-014-1391-y [doi] PST - ppublish SO - Obes Surg. 2015 Feb;25(2):199-208. doi: 10.1007/s11695-014-1391-y.