PMID- 25103650
OWN - NLM
STAT- MEDLINE
DCOM- 20150204
LR  - 20161013
IS  - 1715-3360 (Electronic)
IS  - 0008-4182 (Linking)
VI  - 49
IP  - 4
DP  - 2014 Aug
TI  - Spectral-domain optical coherence tomography features preceding new-onset 
      neovascular membrane formation.
PG  - 339-44
LID - S0008-4182(14)00167-7 [pii]
LID - 10.1016/j.jcjo.2014.04.018 [doi]
AB  - OBJECTIVE: To determine the frequency and characteristic spectral-domain optical 
      coherence tomography (SD-OCT) features preceding new-onset choroidal 
      neovascularization (CNV) in the fellow eye of neovascular age-related macular 
      degeneration (AMD) with SD-OCT. DESIGN: A prospective, observational study. 
      PARTICIPANTS: Sixty-eight fellow eyes of patients with unilateral CNV. METHODS: 
      SD-OCT was performed at baseline and then monthly. The main outcome measure is 
      the description of retinal morphology 1 month before new onset of 
      neovascularization. RESULTS: During the 48-month observation period, new-onset 
      CNV was observed in 27 fellow eyes. Several morphologic features characterized 
      SD-OCT images >/=1 months before new onset of CNV. These included new retinal 
      pigment epithelium defects (2 eyes), new photoreceptor defects (7 eyes), drusen 
      touching the photoreceptor layer and the external limiting membrane (13 eyes), 
      and new drusen (4 eyes) hyperreflective spots probably representing new growing 
      vessels (5 eyes). CONCLUSIONS: Monthly SD-OCT screening of fellow eyes of 
      patients treated with anti-vascular endothelial growth factor enables 
      identification of morphologic changes that may predispose or precede CNV 
      formation. Rapid identification of CNV formation enhances treatment immediacy.
CI  - Copyright (c) 2014 Canadian Ophthalmological Society. Published by Elsevier Inc. 
      All rights reserved.
FAU - Michalewski, Janusz
AU  - Michalewski J
AD  - Ophthalmic Clinic "Jasne Blonia" Rojna 90, 91-162 Lodz, Poland.
FAU - Nawrocki, Jerzy
AU  - Nawrocki J
AD  - Ophthalmic Clinic "Jasne Blonia" Rojna 90, 91-162 Lodz, Poland.
FAU - Trebinska, Magdalena
AU  - Trebinska M
AD  - III Municipal Hospital, K. Jonscher, Milionowa 14 Lodz, Poland.
FAU - Michalewska, Zofia
AU  - Michalewska Z
AD  - Ophthalmic Clinic "Jasne Blonia" Rojna 90, 91-162 Lodz, Poland. Electronic 
      address: zosia_n@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - England
TA  - Can J Ophthalmol
JT  - Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
JID - 0045312
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiogenesis Inhibitors/therapeutic use
MH  - Basement Membrane/pathology
MH  - Choroidal Neovascularization/*diagnosis/drug therapy
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Photoreceptor Cells, Vertebrate/pathology
MH  - Prospective Studies
MH  - Retinal Drusen/pathology
MH  - Retinal Pigment Epithelium/pathology
MH  - *Tomography, Optical Coherence
MH  - Vascular Endothelial Growth Factor A/antagonists & inhibitors
MH  - Wet Macular Degeneration/*diagnosis/drug therapy
EDAT- 2014/08/12 06:00
MHDA- 2015/02/05 06:00
CRDT- 2014/08/09 06:00
PHST- 2013/12/12 00:00 [received]
PHST- 2014/04/05 00:00 [revised]
PHST- 2014/05/06 00:00 [accepted]
PHST- 2014/08/09 06:00 [entrez]
PHST- 2014/08/12 06:00 [pubmed]
PHST- 2015/02/05 06:00 [medline]
AID - S0008-4182(14)00167-7 [pii]
AID - 10.1016/j.jcjo.2014.04.018 [doi]
PST - ppublish
SO  - Can J Ophthalmol. 2014 Aug;49(4):339-44. doi: 10.1016/j.jcjo.2014.04.018.