PMID- 25104103
OWN - NLM
STAT- MEDLINE
DCOM- 20141114
LR  - 20181202
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 63
IP  - 10
DP  - 2014 Oct
TI  - The role of the kidneys in glucose homeostasis in type 2 diabetes: clinical 
      implications and therapeutic significance through sodium glucose co-transporter 2 
      inhibitors.
PG  - 1228-37
LID - S0026-0495(14)00195-4 [pii]
LID - 10.1016/j.metabol.2014.06.018 [doi]
AB  - The kidneys play an important role in regulating glucose homeostasis through 
      utilization of glucose, gluconeogenesis, and glucose reabsorption via sodium 
      glucose co-transporters (SGLTs) and glucose transporters. The renal threshold for 
      glucose excretion (RTG) is increased in patients with type 2 diabetes mellitus 
      (T2DM), possibly due to upregulation of SGLT2 and SGLT1 expression. The resulting 
      increase in renal glucose reabsorption is thought to contribute to the 
      maintenance of hyperglycemia in patients with T2DM. Selective SGLT2 inhibitors 
      reduce the RTG, thereby increasing glucosuria, and have demonstrated favorable 
      efficacy and safety in patients with T2DM inadequately controlled with diet and 
      exercise and other glucose-lowering treatments.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Wilding, John P H
AU  - Wilding JP
AD  - Department of Obesity and Endocrinology, University of Liverpool, United Kingdom. 
      Electronic address: J.P.H.Wilding@liverpool.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140702
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Sodium-Glucose Transporter 2)
RN  - 0 (Sodium-Glucose Transporter 2 Inhibitors)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*metabolism/physiopathology
MH  - Glucose/*metabolism
MH  - Homeostasis/*physiology
MH  - Humans
MH  - Kidney/*metabolism/physiopathology
MH  - Sodium-Glucose Transporter 2/*metabolism
MH  - *Sodium-Glucose Transporter 2 Inhibitors
OTO - NOTNLM
OT  - Kidneys
OT  - Sodium glucose co-transporter 2 (SGLT2) inhibitor
OT  - Type 2 diabetes mellitus
EDAT- 2014/08/12 06:00
MHDA- 2014/11/15 06:00
CRDT- 2014/08/09 06:00
PHST- 2014/02/10 00:00 [received]
PHST- 2014/06/30 00:00 [revised]
PHST- 2014/06/30 00:00 [accepted]
PHST- 2014/08/09 06:00 [entrez]
PHST- 2014/08/12 06:00 [pubmed]
PHST- 2014/11/15 06:00 [medline]
AID - S0026-0495(14)00195-4 [pii]
AID - 10.1016/j.metabol.2014.06.018 [doi]
PST - ppublish
SO  - Metabolism. 2014 Oct;63(10):1228-37. doi: 10.1016/j.metabol.2014.06.018. Epub 
      2014 Jul 2.