PMID- 25104464
OWN - NLM
STAT- MEDLINE
DCOM- 20150129
LR  - 20220408
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 252
IP  - 9
DP  - 2014 Sep
TI  - Macular ganglion cell-inner plexiform layer thinning in patients with visual 
      field defect that respects the vertical meridian.
PG  - 1501-7
LID - 10.1007/s00417-014-2706-3 [doi]
AB  - The aim of this work is to compare the thinning patterns of the ganglion cell 
      inner-plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) 
      as measured using Cirrus high-definition optical coherence tomography (HD-OCT) in 
      patients with visual field (VF) defects that respect the vertical meridian. 
      Twenty eyes of 11 patients with VF defects that respect the vertical meridian 
      were enrolled retrospectively. The thicknesses of the macular GCIPL and pRNFL 
      were measured using Cirrus HD-OCT. The 5 and 1% thinning area index (TAI) was 
      calculated as the proportion of abnormally thin sectors at the 5 and 1% 
      probability level within the area corresponding to the affected VF. The 5 and 1% 
      TAI were compared between the GCIPL and pRNFL measurements. The color-coded GCIPL 
      deviation map showed a characteristic vertical thinning pattern of the GCIPL, 
      which is also seen in the VF of patients with brain lesions. The 5 and 1% TAI 
      were significantly higher in the GCIPL measurements than in the pRNFL 
      measurements (all p < 0.01). Macular GCIPL analysis clearly visualized a 
      characteristic topographic pattern of retinal ganglion cell (RGC) loss in 
      patients with VF defects that respect the vertical meridian, unlike pRNFL 
      measurements. Macular GCIPL measurements provide more valuable information than 
      pRNFL measurements for detecting the loss of RGCs in patients with retrograde 
      degeneration of the optic nerve fibers.
FAU - Shin, Hye-Young
AU  - Shin HY
AD  - Department of Ophthalmology, Uijeongbu St. Mary's Hospital, College of Medicine, 
      Catholic University of Korea, Seoul, South Korea.
FAU - Park, Hae-Young Lopilly
AU  - Park HY
FAU - Choi, Jin-A
AU  - Choi JA
FAU - Park, Chan Kee
AU  - Park CK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20140809
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hemianopsia/*diagnosis/physiopathology
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Tonometry, Ocular
MH  - Visual Field Tests
MH  - Visual Fields/*physiology
MH  - Young Adult
EDAT- 2014/08/12 06:00
MHDA- 2015/01/30 06:00
CRDT- 2014/08/09 06:00
PHST- 2013/12/11 00:00 [received]
PHST- 2014/06/23 00:00 [accepted]
PHST- 2014/05/11 00:00 [revised]
PHST- 2014/08/09 06:00 [entrez]
PHST- 2014/08/12 06:00 [pubmed]
PHST- 2015/01/30 06:00 [medline]
AID - 10.1007/s00417-014-2706-3 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2014 Sep;252(9):1501-7. doi: 
      10.1007/s00417-014-2706-3. Epub 2014 Aug 9.