PMID- 25104829
OWN - NLM
STAT- MEDLINE
DCOM- 20140925
LR  - 20211021
IS  - 1534-7362 (Electronic)
IS  - 1534-7362 (Linking)
VI  - 14
IP  - 9
DP  - 2014 Aug 7
TI  - Paradoxical visuomotor adaptation to reversed visual input is predicted by BDNF 
      Val66Met polymorphism.
LID - 10.1167/14.9.4 [doi]
LID - 4
AB  - Brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the 
      brain, influencing neural development, plasticity, and repair (Chen et al., 2004; 
      Thoenen, 1995). The BDNF gene contains a single-nucleotide polymorphism (SNP) 
      called Val(66)Met. The Met allele interferes with intracellular BDNF-trafficking, 
      decreases activity-dependent BDNF secretion, and consequently is often associated 
      with a shift from plasticity to stability in neural circuits (Egan et al., 2003). 
      We investigated the behavioral consequences of the presence of the Met allele by 
      comparing how 40 heterozygous subjects with the Val/Met genotype and 35 
      homozygous subjects with the Val/Val genotype performed on visuomotor tasks 
      (reaching and navigation) under two conditions: normal vision and completely 
      left-right reversed vision. As expected, subjects did not differ in their 
      short-term ability to learn the tasks with normal vision (p = 0.58). Intuitively, 
      it would be expected that homozygous Val/Val subjects with a propensity for 
      greater BDNF-induced activity-dependent plasticity would learn new tasks more 
      quickly than heterozygous Val/Met subjects with decreased BDNF secretion 
      (Gilbert, Li, & Piech, 2009). However, we found the opposite here. When 
      short-term mechanisms of visuomotor adaptation were engaged to compensate for the 
      misalignment of visual and somatomotor information created by the left-right 
      reversal of vision, heterozygous Val/Met subjects learned significantly more 
      quickly than their homozygous Val/Val counterparts (p = 0.027). Our results 
      demonstrate the paradoxical finding that the presence of the Met allele, which is 
      thought to promote cortical stability, here improves immediate visuomotor 
      adaptation to left-right-reversed visual input.
CI  - (c) 2014 ARVO.
FAU - Barton, Brian
AU  - Barton B
AD  - Department of Cognitive Sciences, University of California, Irvine, CA, USA.
FAU - Treister, Andrew
AU  - Treister A
AD  - Department of Neurology, University of California, Irvine, CA, USA.
FAU - Humphrey, Melanie
AU  - Humphrey M
AD  - Department of Cognitive Sciences, University of California, Irvine, CA, USA.
FAU - Abedi, Garen
AU  - Abedi G
AD  - Department of Neurology, University of California, Irvine, CA, USA.
FAU - Cramer, Steven C
AU  - Cramer SC
AD  - Departments of Anatomy and Neurobiology and Neurology, University of California, 
      Irvine, CA, USA.
FAU - Brewer, Alyssa A
AU  - Brewer AA
AD  - Department of Cognitive Sciences, University of California, Irvine, CA, USA.
LA  - eng
GR  - K24 HD074722/HD/NICHD NIH HHS/United States
GR  - L30 EY019249/EY/NEI NIH HHS/United States
GR  - R01 NS058755/NS/NINDS NIH HHS/United States
GR  - UL1 TR000153/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140807
PL  - United States
TA  - J Vis
JT  - Journal of vision
JID - 101147197
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adaptation, Ocular/*genetics
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Chromatography, High Pressure Liquid
MH  - *Eyeglasses
MH  - Female
MH  - Functional Laterality/physiology
MH  - Genotype
MH  - Humans
MH  - Learning/physiology
MH  - Male
MH  - Neuronal Plasticity/physiology
MH  - Pattern Recognition, Visual/*physiology
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Psychomotor Performance/*physiology
MH  - Vision, Binocular/genetics
MH  - Visual Pathways/physiology
MH  - Young Adult
PMC - PMC4125061
OTO - NOTNLM
OT  - BDNF
OT  - plasticity
OT  - prism adaptation
OT  - vision
OT  - visuomotor
EDAT- 2014/08/12 06:00
MHDA- 2014/09/26 06:00
PMCR- 2014/08/07
CRDT- 2014/08/09 06:00
PHST- 2014/08/09 06:00 [entrez]
PHST- 2014/08/12 06:00 [pubmed]
PHST- 2014/09/26 06:00 [medline]
PHST- 2014/08/07 00:00 [pmc-release]
AID - 14.9.4 [pii]
AID - 10.1167/14.9.4 [doi]
PST - epublish
SO  - J Vis. 2014 Aug 7;14(9):4. doi: 10.1167/14.9.4.