PMID- 25106034 OWN - NLM STAT- MEDLINE DCOM- 20150723 LR - 20220408 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 168 DP - 2014 Oct TI - Serum Brain-derived neurotrophic factor levels in post-stroke depression. PG - 373-9 LID - S0165-0327(14)00442-X [pii] LID - 10.1016/j.jad.2014.07.011 [doi] AB - BACKGROUND: Depression is a frequent mood disorder that affects around a third of stroke patients and has been associated with poorer outcome. Our aim was to determine whether there is a relationship between serum Brain-derived neurotrophic factor (BDNF) levels and post-stroke depression (PSD). METHODS: Two hundred and sixteen ischemic stroke patients admitted to the hospital within the first 24h after stroke onset were consecutively recruited and followed up for 3 months. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for post-stroke depression at day 90. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of BDNF at admission. Multivariate analyses were performed using logistic regression models. RESULTS: In our study, 59 patients (27.3%) were diagnosed as having major depression at 3 months. Patients with major depression showed lower levels of serum BDNF [8.1 (5.6-9.4) vs. 13.7 (10.4-16.5)ng/ml, P<0.0001] at admission. In multivariate analyses, serum BDNF was an independent predictor of PSD at 3 months [odds ratio (OR): 0.79(0.72-0.87), P=0.003]. Serum levels of BDNF