PMID- 25110491
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140811
LR  - 20211021
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 11
IP  - 3
DP  - 2014 Jul
TI  - The potential role of monocyte chemoattractant protein-1 for major depressive 
      disorder.
PG  - 217-22
LID - 10.4306/pi.2014.11.3.217 [doi]
AB  - The immune hypothesis of major depressive disorder (MDD) fits well with the 
      supposed interaction between genetic and environmental factors in disorders with 
      a complicated etiopathogenesis. It has been suggested that infectious diseases 
      are associated with MDD in that cytokines may play a critical role as a key 
      modulator in the transition between infection and the development of MDD. It has 
      been also suggested that antidepressants have immunomodulatory effects on some 
      cytokines and cytokine receptors, although the exact mechanism has not yet been 
      fully elucidated. Among cytokines, monocyte chemoattractant protein-1 (MCP-1) is 
      especially well known and has attracted considerable interest owing to its 
      immunomodulatory functions. MCP-1 is expressed in highly regionalized neuronal 
      areas in the brain, leading to kind of modulation of neuronal activity and 
      neuroendocrine functions commonly seen in patients with MDD. Additionally, it is 
      involved in the control of other cytokines that have been consistently proposed 
      as associated with the development of MDD. It also has a possible role in the 
      neurodegenerative process of a number of central nervous system (CNS) diseases. 
      Hence, this paper draws from the perspective of immunology to offer several 
      suggestions about the role of MPC-1 in the development of MDD.
FAU - Pae, Chi-Un
AU  - Pae CU
AD  - Department of Psychiatry, Bucheon St. Mary's Hospital, The Catholic University of 
      Korea College of Medicine, Seoul, Republic of Korea. ; Department of Psychiatry 
      and Behavioral Medicines, Duke University Medical Center, Durham, NC, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140721
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC4124177
OTO - NOTNLM
OT  - Antidepressant
OT  - Depression
OT  - Monocyte chemoattractant protein-1
OT  - Neurodegeneration
OT  - Neuroprotection
OT  - Pathophysiology
EDAT- 2014/08/12 06:00
MHDA- 2014/08/12 06:01
PMCR- 2014/07/01
CRDT- 2014/08/12 06:00
PHST- 2013/07/09 00:00 [received]
PHST- 2013/07/23 00:00 [revised]
PHST- 2013/07/23 00:00 [accepted]
PHST- 2014/08/12 06:00 [entrez]
PHST- 2014/08/12 06:00 [pubmed]
PHST- 2014/08/12 06:01 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - 10.4306/pi.2014.11.3.217 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2014 Jul;11(3):217-22. doi: 10.4306/pi.2014.11.3.217. Epub 
      2014 Jul 21.