PMID- 25110503
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140811
LR  - 20211021
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 11
IP  - 3
DP  - 2014 Jul
TI  - Chronic administration of bacopa monniera increases BDNF protein and mRNA 
      expressions: a study in chronic unpredictable stress induced animal model of 
      depression.
PG  - 297-306
LID - 10.4306/pi.2014.11.3.297 [doi]
AB  - OBJECTIVE: The present study aimed to investigate whether graded doses of Bacopa 
      Monniera (BM) extract could produce antidepressant-like effects in chronic 
      unpredictable stress (CUS) induced depression in rats and its possible 
      mechanism(s). METHODS: Rats were subjected to an experimental setting of CUS. The 
      effect of BM extract treatment in CUS-induced depression was examined using 
      behavioral tests including the sucrose consumption, open field test and shuttle 
      box escape test. The mechanism underlying the antidepressant-like action of BM 
      extract was examined by measuring brain-derived neurotrophic factor (BDNF) 
      protein and mRNA expression in brain tissues of CUS-exposed rats. RESULTS: 
      Exposure to CUS for 4 weeks caused depression-like behavior in rats, as indicated 
      by significant decreases in sucrose consumption, locomotor activity and escape 
      latency. In addition, it was found that BDNF protein and mRNA levels in the 
      hippocampus and frontal cortex were lower in CUS-treated rats, as compared to 
      controls. Daily administration of the graded doses of BM extract during the 
      4-week period of CUS significantly suppressed behavioral changes and attenuated 
      the CUS-induced decrease in BDNF protein and mRNA levels in the hippocampus and 
      frontal cortex. CONCLUSION: The results suggest that BM extract alleviates 
      depression induced by CUS. Present study also confirms that 80-120 mg/kg doses of 
      BM extract have significantly higher antidepressant-like activity.
FAU - Banerjee, Ritabrata
AU  - Banerjee R
AD  - Department of Physiology, Raja Peary Mohan College, Uttarpara, Hooghly, West 
      Bengal, India.
FAU - Hazra, Somoday
AU  - Hazra S
AD  - Department of Physiology, Raja Peary Mohan College, Uttarpara, Hooghly, West 
      Bengal, India.
FAU - Ghosh, Anup Kumar
AU  - Ghosh AK
AD  - Department of Instrumentation Science, Jadavpur University, Calcutta, West 
      Bengal, India.
FAU - Mondal, Amal Chandra
AU  - Mondal AC
AD  - Department of Physiology, Raja Peary Mohan College, Uttarpara, Hooghly, West 
      Bengal, India.
LA  - eng
PT  - Journal Article
DEP - 20140721
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC4124189
OTO - NOTNLM
OT  - Antidepressant
OT  - BDNF
OT  - Bacopa monniera
OT  - Chronic unpredictable stress
OT  - Open field test
OT  - Shuttle box escape test
OT  - Sucrose consumption
OT  - TrkB
EDAT- 2014/08/12 06:00
MHDA- 2014/08/12 06:01
PMCR- 2014/07/01
CRDT- 2014/08/12 06:00
PHST- 2013/05/06 00:00 [received]
PHST- 2013/07/20 00:00 [revised]
PHST- 2013/08/02 00:00 [accepted]
PHST- 2014/08/12 06:00 [entrez]
PHST- 2014/08/12 06:00 [pubmed]
PHST- 2014/08/12 06:01 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - 10.4306/pi.2014.11.3.297 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2014 Jul;11(3):297-306. doi: 10.4306/pi.2014.11.3.297. Epub 
      2014 Jul 21.