PMID- 25110539
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140811
LR  - 20211021
IS  - 1918-3003 (Print)
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Linking)
VI  - 6
IP  - 5
DP  - 2014 Oct
TI  - Effect of statins on endothelial function in patients with acute coronary 
      syndrome: a prospective study using adhesion molecules and flow-mediated 
      dilatation.
PG  - 354-61
LID - 10.14740/jocmr1863w [doi]
AB  - BACKGROUND: Accumulating evidence suggests that inflammatory mechanisms play a 
      central role in the development, progression and outcome of atherosclerosis. 
      Recent evidence suggests that statins improve anti-inflammatory, anti-thrombotic 
      and endothelial functions, along with their lipid-decreasing effects. We examined 
      the effect of statins on endothelial function using biochemical markers of 
      endothelial dysfunction and brachial artery flow-mediated dilatation (FMD). 
      METHODS: Thirty male patients presenting with acute coronary syndrome (ACS) and 
      26 age-matched healthy control subjects aged 40 - 60 years who were not on any 
      medication were enrolled in the study. The patient group was started on 
      atorvastatin (40 mg/day) without consideration of their low-density lipoprotein 
      (LDL)-cholesterol levels. Endothelin, sICAM and E-selectin from stored serum 
      samples were measured using commercially available enzyme-linked immunosorbant 
      assays (ELISAs). Endothelial function was assessed using brachial artery FMD. 
      RESULTS: Prior to statin treatment, E-selectin, sICAM and endothelin levels, 
      endothelial dysfunction markers, were 99.74 +/- 34.67 ng/mL, 568.8 +/- 149.0 ng/mL 
      and 0.62 +/- 0.33 fmol/mL, respectively in the patient group. E-selectin and sICAM 
      levels were significantly higher in the patients than in the control subjects (P 
      < 0.001); however, endothelin levels were not significantly different between 
      groups. Statin treatment significantly reduced E-selectin and sICAM levels (P < 
      0.001); however, the decrease in endothelin levels was not statistically 
      significant. %FMD values were significantly increased after statin treatment (P = 
      0.005), and levels of C-reactive protein (CRP), an inflammation marker, were 
      significantly reduced. CONCLUSION: Our results indicate that statins play an 
      important role in treatment endothelial dysfunction by reducing adhesion of 
      inflammatory cells.
FAU - Altun, Ibrahim
AU  - Altun I
AD  - Department of Cardiology, Istanbul School of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Oz, Fahrettin
AU  - Oz F
AD  - Department of Cardiology, Istanbul School of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Arkaya, Selda Can
AU  - Arkaya SC
AD  - Department of Biochemistry, Istanbul School of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Altun, Ilknur
AU  - Altun I
AD  - Department of Radiology, Sisli Etfal Training and Research Hospital, 
      Sisli-Istanbul, Turkey.
FAU - Bilge, Ahmet Kaya
AU  - Bilge AK
AD  - Department of Cardiology, Istanbul School of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Umman, Berrin
AU  - Umman B
AD  - Department of Cardiology, Istanbul School of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Turkoglu, Umit Mutlu
AU  - Turkoglu UM
AD  - Department of Biochemistry, Istanbul School of Medicine, Istanbul University, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20140728
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC4125330
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Adhesion molecules
OT  - Flow-mediated dilatation
OT  - Statins
OT  - Ultrasonography
EDAT- 2014/08/12 06:00
MHDA- 2014/08/12 06:01
PMCR- 2014/07/28
CRDT- 2014/08/12 06:00
PHST- 2014/05/15 00:00 [accepted]
PHST- 2014/08/12 06:00 [entrez]
PHST- 2014/08/12 06:00 [pubmed]
PHST- 2014/08/12 06:01 [medline]
PHST- 2014/07/28 00:00 [pmc-release]
AID - 10.14740/jocmr1863w [doi]
PST - ppublish
SO  - J Clin Med Res. 2014 Oct;6(5):354-61. doi: 10.14740/jocmr1863w. Epub 2014 Jul 28.