PMID- 25112605
OWN - NLM
STAT- MEDLINE
DCOM- 20141204
LR  - 20220321
IS  - 1759-4804 (Electronic)
IS  - 1759-4790 (Linking)
VI  - 10
IP  - 10
DP  - 2014 Oct
TI  - Adverse reactions to biologic agents and their medical management.
PG  - 612-27
LID - 10.1038/nrrheum.2014.123 [doi]
AB  - Biologic agents have substantially advanced the treatment of immunological 
      disorders, including chronic inflammatory and autoimmune diseases. However, these 
      drugs are often associated with adverse events (AEs), including allergic, 
      immunological and other unwanted reactions. AEs can affect almost any organ or 
      system in the body and can occur immediately, within minutes to hours, or with a 
      delay of several days or more after initiation of biologic therapy. Although some 
      AEs are a direct consequence of the functional inhibition of 
      biologic-agent-targeted antigens, the pathogenesis of other AEs results from a 
      drug-induced imbalance of the immune system, intermediary factors and cofactors, 
      a complexity that complicates their prediction. Herein, we review the AEs 
      associated with biologic therapy most relevant to rheumatic and immunological 
      diseases, and discuss their underlying pathogenesis. We also include our 
      recommendations for the medical management of such AEs. Increased understanding 
      and improved risk management of AEs induced by biologic agents will enable better 
      use of these versatile immune-response modifiers.
FAU - Boyman, Onur
AU  - Boyman O
AD  - Department of Immunology, University Hospital Zurich, Gloriastrasse 30, CH-8091 
      Zurich, Switzerland.
FAU - Comte, Denis
AU  - Comte D
AD  - Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Rue 
      du Bugnon 46, CH-1011 Lausanne, Switzerland.
FAU - Spertini, Francois
AU  - Spertini F
AD  - Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Rue 
      du Bugnon 46, CH-1011 Lausanne, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140812
PL  - United States
TA  - Nat Rev Rheumatol
JT  - Nature reviews. Rheumatology
JID - 101500080
RN  - 0 (Biological Factors)
SB  - IM
MH  - Biological Factors/*adverse effects/immunology
MH  - Cardiovascular Diseases/etiology
MH  - Gastrointestinal Diseases/etiology
MH  - Hematologic Diseases/etiology
MH  - Humans
MH  - Hypersensitivity/*etiology
MH  - Immune System Diseases/*drug therapy
MH  - Infections/etiology/*immunology
MH  - Lung Diseases/etiology
MH  - Metabolic Diseases/etiology
MH  - Neoplasms/etiology
MH  - Nervous System Diseases/etiology
MH  - Rheumatic Diseases/*drug therapy
MH  - Risk Management
MH  - Skin Diseases/etiology
MH  - Vaccination/adverse effects
MH  - Virus Diseases/etiology
EDAT- 2014/08/13 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/08/13 06:00
PHST- 2014/08/13 06:00 [entrez]
PHST- 2014/08/13 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - nrrheum.2014.123 [pii]
AID - 10.1038/nrrheum.2014.123 [doi]
PST - ppublish
SO  - Nat Rev Rheumatol. 2014 Oct;10(10):612-27. doi: 10.1038/nrrheum.2014.123. Epub 
      2014 Aug 12.