PMID- 25112659
OWN - NLM
STAT- MEDLINE
DCOM- 20150811
LR  - 20230921
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Linking)
VI  - 25
IP  - 1
DP  - 2015 Jan
TI  - BDNF contributes to the facilitation of hippocampal synaptic plasticity and 
      learning enabled by environmental enrichment.
PG  - 1-15
LID - 10.1002/hipo.22342 [doi]
AB  - Sensory, motor, and cognitive stimuli, resulting from interactions with the 
      environment, play a key role in optimizing and modifying the neuronal circuitry 
      required for normal brain function. An experimental animal model for this 
      phenomenon comprises environmental enrichment (EE) in rodents. EE causes profound 
      changes in neuronal and signaling levels of excitation and plasticity throughout 
      the entire central nervous system and the hippocampus is particularly affected. 
      The mechanisms underlying these changes are not yet fully understood. As 
      brain-derived neurotrophic factor (BDNF) supports hippocampal long-term 
      potentiation (LTP), we explored whether it participates in the facilitation of 
      synaptic plasticity and hippocampus-dependent learning that occurs following EE. 
      In the absence of EE, LTP elicited by high-frequency stimulation was equivalent 
      in wildtype mice and heterozygous BDNF(+/-) siblings. LTP elicited by theta-burst 
      stimulation in BDNF(+/-) mice was less than in wildtypes. Long-term depression 
      (LTD) was also impaired. EE for three weeks, beginning after weaning, improved 
      hippocampal LTP in both wildtype and transgenic animals, with LTP in transgenics 
      achieving levels seen in wildtypes in the absence of EE. Object recognition 
      memory was evident in wildtypes 24 h and 7 days after initial object exposure. EE 
      improved memory performance in wildtypes 24 h but not 7 days after initial 
      exposure. BDNF(+/-) mice in the absence of EE showed impaired memory 7 days after 
      initial object exposure that was restored by EE. Western blotting revealed 
      increased levels of BDNF, but not proBDNF, among both EE cohorts. These data 
      support that BDNF plays an intrinsic role in improvements of synaptic plasticity 
      and cognition that occur in EE.
CI  - (c) 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
FAU - Novkovic, Tanja
AU  - Novkovic T
AD  - Medical Faculty, Department of Neurophysiology, Ruhr University Bochum, 44780, 
      Bochum, Germany; International Graduate School of Neuroscience, 44780 Bochum, 
      Germany, 44780, Bochum, Germany.
FAU - Mittmann, Thomas
AU  - Mittmann T
FAU - Manahan-Vaughan, Denise
AU  - Manahan-Vaughan D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140828
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism/*physiology
MH  - *Environment
MH  - Female
MH  - Hippocampus/metabolism/*physiology
MH  - Learning/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neuronal Plasticity/*physiology
MH  - Recognition, Psychology/physiology
OTO - NOTNLM
OT  - CA1
OT  - LTD
OT  - LTP
OT  - enrichment
OT  - object recognition
EDAT- 2014/08/13 06:00
MHDA- 2015/08/12 06:00
CRDT- 2014/08/13 06:00
PHST- 2014/08/05 00:00 [accepted]
PHST- 2014/08/13 06:00 [entrez]
PHST- 2014/08/13 06:00 [pubmed]
PHST- 2015/08/12 06:00 [medline]
AID - 10.1002/hipo.22342 [doi]
PST - ppublish
SO  - Hippocampus. 2015 Jan;25(1):1-15. doi: 10.1002/hipo.22342. Epub 2014 Aug 28.