PMID- 25116057
OWN - NLM
STAT- MEDLINE
DCOM- 20151002
LR  - 20150123
IS  - 1423-0194 (Electronic)
IS  - 0028-3835 (Linking)
VI  - 100
IP  - 2-3
DP  - 2014
TI  - Early paternal deprivation alters levels of hippocampal brain-derived 
      neurotrophic factor and glucocorticoid receptor and serum corticosterone and 
      adrenocorticotropin in a sex-specific way in socially monogamous mandarin voles.
PG  - 119-28
LID - 10.1159/000366441 [doi]
AB  - In monogamous mammals, fathers play an important role in the development of the 
      brain and typical behavior in offspring, but the exact nature of this process is 
      not well understood. In particular, little research has addressed whether the 
      presence or absence of paternal care alters levels of hippocampal glucocorticoid 
      receptor (GR) and brain-derived neurotrophic factor (BDNF), and basal levels of 
      serum corticosterone (CORT) and adrenocorticotropin (ACTH). Here, we explored 
      this concept using socially monogamous mandarin voles (Microtus mandarinus), a 
      species in which fathers display high levels of paternal care toward their pups. 
      Our immunohistochemical study shows that paternal deprivation (PD) significantly 
      decreased levels of GR and BDNF protein in the CA1 and CA2/3 of the hippocampus. 
      In the dental gyrus, decreases in GR and BDNF induced by PD were evident in 
      females but not in males. Additionally, enzyme-linked immunosorbent assay results 
      show that PD significantly upregulated levels of serum CORT and ACTH in females, 
      but not males. These findings demonstrate that PD alters HPA axis activity in a 
      sex-specific way. The changes in stress hormones documented here may be 
      associated with alteration in hippocampal BDNF and GR levels.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Wu, Ruiyong
AU  - Wu R
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, China.
FAU - Song, Zhenzhen
AU  - Song Z
FAU - Wang, Siyang
AU  - Wang S
FAU - Shui, Li
AU  - Shui L
FAU - Tai, Fadao
AU  - Tai F
FAU - Qiao, Xufeng
AU  - Qiao X
FAU - He, Fengqin
AU  - He F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140809
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Arvicolinae/*physiology
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hippocampus/*physiopathology
MH  - Immunohistochemistry
MH  - Male
MH  - *Paternal Deprivation
MH  - Random Allocation
MH  - Receptors, Glucocorticoid/*metabolism
MH  - Sex Characteristics
MH  - Sexual Behavior, Animal/physiology
EDAT- 2014/08/15 06:00
MHDA- 2015/10/03 06:00
CRDT- 2014/08/14 06:00
PHST- 2014/04/03 00:00 [received]
PHST- 2014/07/31 00:00 [accepted]
PHST- 2014/08/14 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2015/10/03 06:00 [medline]
AID - 000366441 [pii]
AID - 10.1159/000366441 [doi]
PST - ppublish
SO  - Neuroendocrinology. 2014;100(2-3):119-28. doi: 10.1159/000366441. Epub 2014 Aug 
      9.