PMID- 2511630
OWN - NLM
STAT- MEDLINE
DCOM- 19900103
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 246
IP  - 4933
DP  - 1989 Nov 24
TI  - Thymic requirement for clonal deletion during T cell development.
PG  - 1044-6
AB  - During T cell differentiation, self tolerance is established in part by the 
      deletion of self-reactive T cells within the thymus (negative selection). The 
      presence of T cell receptor (TCR)-alpha beta + T cells in older athymic (nu/nu) 
      mice indicates that some T cells can also mature without thymic influence. 
      Therefore, to determine whether the thymus is required for negative selection, 
      TCR V beta expression was compared in athymic nu/nu mice and their congenic 
      normal littermates. T cells expressing V beta 3 proteins are specific for minor 
      lymphocyte stimulatory (Mlsc) determinants and are deleted intrathymically due to 
      self tolerance in Mlsc+ mouse strains. Here it is shown that V beta 3+ T cells 
      are deleted in Mlsc+ BALB/c nu/+ mice, but not in their BALB/c nu/nu littermates. 
      Thus, the thymus is required for clonal deletion during T cell development.
FAU - Fry, A M
AU  - Fry AM
AD  - Center for Biologics Evaluation and Research, Food and Drug Administration, 
      Bethesda, MD 20892.
FAU - Jones, L A
AU  - Jones LA
FAU - Kruisbeek, A M
AU  - Kruisbeek AM
FAU - Matis, L A
AU  - Matis LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation, T-Lymphocyte/genetics
MH  - CD4 Antigens/genetics
MH  - CD8 Antigens
MH  - Flow Cytometry
MH  - Gene Expression
MH  - Macromolecular Substances
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred Strains
MH  - Mice, Nude
MH  - Receptors, Antigen, T-Cell/genetics
MH  - T-Lymphocytes/*immunology
MH  - Thymus Gland/*immunology
EDAT- 1989/11/24 00:00
MHDA- 1989/11/24 00:01
CRDT- 1989/11/24 00:00
PHST- 1989/11/24 00:00 [pubmed]
PHST- 1989/11/24 00:01 [medline]
PHST- 1989/11/24 00:00 [entrez]
AID - 10.1126/science.2511630 [doi]
PST - ppublish
SO  - Science. 1989 Nov 24;246(4933):1044-6. doi: 10.1126/science.2511630.