PMID- 25116397
OWN - NLM
STAT- MEDLINE
DCOM- 20151124
LR  - 20150228
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Linking)
VI  - 32
IP  - 5
DP  - 2015 Mar 1
TI  - A potential biomarker in sports-related concussion: brain functional connectivity 
      alteration of the default-mode network measured with longitudinal resting-state 
      fMRI over thirty days.
PG  - 327-41
LID - 10.1089/neu.2014.3413 [doi]
AB  - Current diagnosis and monitoring of sports-related concussion rely on clinical 
      signs and symptoms, and balance, vestibular, and neuropsychological examinations. 
      Conventional brain imaging often does not reveal abnormalities. We sought to 
      assess if the longitudinal change of functional and structural connectivity of 
      the default-mode network (DMN) can serve as a potential biomarker. Eight 
      concussed Division I collegiate football student-athletes in season (one 
      participated twice) and 11 control subjects participated in this study. ImPACT 
      (Immediate Post-Concussion Assessment and Cognitive Testing) was administered 
      over the course of recovery. High-resolution three dimensional T1-weighted, 
      T2*-weighted diffusion-tensor images and resting-state functional magnetic 
      resonance imaging (rs-fMRI) scans were collected from each subject within 24 h, 
      7+/-1 d and 30+/-1 d after concussion. Both network based and whole-brain based 
      functional correlation analyses on DMN were performed. ImPACT findings 
      demonstrated significant cognitive impairment across multiple categories and a 
      significant increase of symptom severity on Day 1 following a concussion but full 
      recovery by 6.0+/-2.4 d. While the structural connectivity within DMN and gross 
      anatomy appeared unchanged, a significantly reduced functional connectivity 
      within DMN from Day 1 to Day 7 was found in the concussed group in this small 
      pilot study. This reduction was seen in eight of our nine concussion cases. 
      Compared with the control group, there appears a general trend of increased DMN 
      functional connectivity on Day 1, a significant drop on Day 7, and partial 
      recovery on Day 30. The results of this pilot study suggest that the functional 
      connectivity of DMN measured with longitudinal rs-fMRI can serve as a potential 
      biomarker to monitor the dynamically changing brain function after sports-related 
      concussion, even in patients who have shown clinical improvement.
FAU - Zhu, David C
AU  - Zhu DC
AD  - 1 Department of Radiology, Michigan State University , East Lansing, Michigan.
FAU - Covassin, Tracey
AU  - Covassin T
FAU - Nogle, Sally
AU  - Nogle S
FAU - Doyle, Scarlett
AU  - Doyle S
FAU - Russell, Doozie
AU  - Russell D
FAU - Pearson, Randolph L
AU  - Pearson RL
FAU - Monroe, Jeffrey
AU  - Monroe J
FAU - Liszewski, Christine M
AU  - Liszewski CM
FAU - DeMarco, J Kevin
AU  - DeMarco JK
FAU - Kaufman, David I
AU  - Kaufman DI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141216
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
SB  - IM
MH  - Brain Injuries/*diagnosis/*physiopathology
MH  - Diffusion Magnetic Resonance Imaging
MH  - Football/*injuries
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Imaging, Three-Dimensional/*methods
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/physiopathology
MH  - Pilot Projects
MH  - Young Adult
OTO - NOTNLM
OT  - default-mode network
OT  - diffusion-tensor imaging
OT  - mild traumatic brain injury
OT  - resting-state fMRI
OT  - sports-related concussion
EDAT- 2014/08/15 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/08/14 06:00
PHST- 2014/08/14 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1089/neu.2014.3413 [doi]
PST - ppublish
SO  - J Neurotrauma. 2015 Mar 1;32(5):327-41. doi: 10.1089/neu.2014.3413. Epub 2014 Dec 
      16.